000056080 001__ 56080
000056080 005__ 20200221144343.0
000056080 0247_ $$2doi$$a10.3390/app6070186
000056080 0248_ $$2sideral$$a95100
000056080 037__ $$aART-2016-95100
000056080 041__ $$aeng
000056080 100__ $$0(orcid)0000-0002-6305-9283$$aManzano, Sara
000056080 245__ $$aAltered Mechano-Electrochemical Behavior of Articular Cartilage in Populations with Obesity
000056080 260__ $$c2016
000056080 5060_ $$aAccess copy available to the general public$$fUnrestricted
000056080 5203_ $$aObesity, one of the major problems in modern society, adversely affects people’s health and increases the risk of suffering degeneration in supportive tissues such as cartilage, which loses its ability to support and distribute loads. However, no specific research regarding obesity-associated alterations in the mechano-electrochemical cartilage environment has been developed. Such studies could help us to understand the first signs of cartilage degeneration when body weight increases and to establish preventive treatments to avoid cartilage deterioration. In this work, a previous mechano-electrochemical computational model has been further developed and employed to analyze and quantify the effects of obesity on the articular cartilage of the femoral hip. A comparison between the obtained results of the healthy and osteoarthritic cartilage has been made. It shows that behavioral patterns of cartilage, such as ion fluxes and cation distribution, have considerable similarities with those obtained for the early stages of osteoarthritis. Thus, an increment in the outgoing ion fluxes is produced, resulting in lower cation concentrations in all the cartilage layers. These results suggest that people with obesity, i.e. a body mass index greater than 30 kg/m2, should undergo preventive treatments for osteoarthritis to avoid homeostatic alterations and, subsequent, tissue deterioration.
000056080 536__ $$9info:eu-repo/grantAgreement/ES/MEC/FPU-AP2010-2557$$9info:eu-repo/grantAgreement/ES/MINECO/MAT2013-46467-C4-3-R
000056080 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000056080 590__ $$a1.679$$b2016
000056080 591__ $$aMATERIALS SCIENCE, MULTIDISCIPLINARY$$b150 / 275 = 0.545$$c2016$$dQ3$$eT2
000056080 591__ $$aCHEMISTRY, MULTIDISCIPLINARY$$b91 / 166 = 0.548$$c2016$$dQ3$$eT2
000056080 591__ $$aPHYSICS, APPLIED$$b75 / 147 = 0.51$$c2016$$dQ3$$eT2
000056080 592__ $$a0.315$$b2016
000056080 593__ $$aFluid Flow and Transfer Processes$$c2016$$dQ2
000056080 593__ $$aMaterials Science (miscellaneous)$$c2016$$dQ2
000056080 593__ $$aEngineering (miscellaneous)$$c2016$$dQ2
000056080 593__ $$aProcess Chemistry and Technology$$c2016$$dQ3
000056080 593__ $$aInstrumentation$$c2016$$dQ3
000056080 593__ $$aComputer Science Applications$$c2016$$dQ3
000056080 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000056080 700__ $$0(orcid)0000-0001-8741-6452$$aDoblare, Manuel$$uUniversidad de Zaragoza
000056080 700__ $$0(orcid)0000-0003-0088-7222$$aHamdy Doweidar, Mohamed$$uUniversidad de Zaragoza
000056080 7102_ $$15004$$2605$$aUniversidad de Zaragoza$$bDpto. Ingeniería Mecánica$$cÁrea Mec.Med.Cont. y Teor.Est.
000056080 773__ $$g6, 7 (2016), 6070186 [13p]$$pAppl. sci.$$tApplied Sciences (Switzerland)$$x2076-3417
000056080 8564_ $$s2505707$$uhttps://zaguan.unizar.es/record/56080/files/texto_completo.pdf$$yVersión publicada
000056080 8564_ $$s107602$$uhttps://zaguan.unizar.es/record/56080/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000056080 909CO $$ooai:zaguan.unizar.es:56080$$particulos$$pdriver
000056080 951__ $$a2020-02-21-13:51:25
000056080 980__ $$aARTICLE