56080 20200221144343.0 doi 10.3390/app6070186 sideral 95100 ART-2016-95100 eng (orcid)0000-0002-6305-9283 Manzano, Sara Altered Mechano-Electrochemical Behavior of Articular Cartilage in Populations with Obesity 2016 Access copy available to the general public Unrestricted Obesity, one of the major problems in modern society, adversely affects people’s health and increases the risk of suffering degeneration in supportive tissues such as cartilage, which loses its ability to support and distribute loads. However, no specific research regarding obesity-associated alterations in the mechano-electrochemical cartilage environment has been developed. Such studies could help us to understand the first signs of cartilage degeneration when body weight increases and to establish preventive treatments to avoid cartilage deterioration. In this work, a previous mechano-electrochemical computational model has been further developed and employed to analyze and quantify the effects of obesity on the articular cartilage of the femoral hip. A comparison between the obtained results of the healthy and osteoarthritic cartilage has been made. It shows that behavioral patterns of cartilage, such as ion fluxes and cation distribution, have considerable similarities with those obtained for the early stages of osteoarthritis. Thus, an increment in the outgoing ion fluxes is produced, resulting in lower cation concentrations in all the cartilage layers. These results suggest that people with obesity, i.e. a body mass index greater than 30 kg/m2, should undergo preventive treatments for osteoarthritis to avoid homeostatic alterations and, subsequent, tissue deterioration. info:eu-repo/grantAgreement/ES/MEC/FPU-AP2010-2557 info:eu-repo/grantAgreement/ES/MINECO/MAT2013-46467-C4-3-R info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 1.679 2016 MATERIALS SCIENCE, MULTIDISCIPLINARY 150 / 275 = 0.545 2016 Q3 T2 CHEMISTRY, MULTIDISCIPLINARY 91 / 166 = 0.548 2016 Q3 T2 PHYSICS, APPLIED 75 / 147 = 0.51 2016 Q3 T2 0.315 2016 Fluid Flow and Transfer Processes 2016 Q2 Materials Science (miscellaneous) 2016 Q2 Engineering (miscellaneous) 2016 Q2 Process Chemistry and Technology 2016 Q3 Instrumentation 2016 Q3 Computer Science Applications 2016 Q3 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion (orcid)0000-0001-8741-6452 Doblare, Manuel Universidad de Zaragoza (orcid)0000-0003-0088-7222 Hamdy Doweidar, Mohamed Universidad de Zaragoza 5004 605 Universidad de Zaragoza Dpto. Ingeniería Mecánica Área Mec.Med.Cont. y Teor.Est. 6, 7 (2016), 6070186 [13p] Appl. sci. Applied Sciences (Switzerland) 2076-3417 2505707 http://zaguan.unizar.es/record/56080/files/texto_completo.pdf Versión publicada 107602 http://zaguan.unizar.es/record/56080/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:56080 articulos driver 2020-02-21-13:51:25 ARTICLE