000056081 001__ 56081
000056081 005__ 20200221144200.0
000056081 0247_ $$2doi$$a10.1371/journal.pone.0157967
000056081 0248_ $$2sideral$$a95096
000056081 037__ $$aART-2016-95096
000056081 041__ $$aeng
000056081 100__ $$0(orcid)0000-0002-6305-9283$$aManzano, Sara
000056081 245__ $$aInhomogeneous response of articular cartilage: A three-dimensional multiphasic heterogeneous study
000056081 260__ $$c2016
000056081 5060_ $$aAccess copy available to the general public$$fUnrestricted
000056081 5203_ $$aArticular cartilage exhibits complex mechano-electrochemical behaviour due to its anisotropy, inhomogeneity and material non-linearity. In this work, the thickness and radial dependence of cartilage properties are incorporated into a 3D mechano-electrochemical model to explore the relevance of heterogeneity in the behaviour of the tissue. The model considers four essential phenomena: (i) osmotic pressure, (ii) convective and diffusive processes, (iii) chemical expansion and (iv) three-dimensional through-the-thickness heterogeneity of the tissue. The need to consider heterogeneity in computational simulations of cartilage behaviour and in manufacturing biomaterials mimicking this tissue is discussed. To this end, healthy tibial plateaus from pigs were mechanically and biochemically tested in-vitro. Heterogeneous properties were included in the mechano-electrochemical computational model to simulate tissue swelling. The simulation results demonstrated that swelling of the heterogeneous samples was significantly lower than swelling under homogeneous and isotropic conditions. Furthermore, there was a significant reduction in the flux of water and ions in the former samples. In conclusion, the computational model presented here can be con- sidered as a valuable tool for predicting how the variation of cartilage properties affects its behaviour, opening up possibilities for exploring the requirements of cartilage-mimicking biomaterials for tissue engineering. Besides, the model also allows the establishment of behavioural patterns of swelling and of water and ion fluxes in articular cartilage.
000056081 536__ $$9info:eu-repo/grantAgreement/ES/MEC/FPU-AP2010-2557$$9info:eu-repo/grantAgreement/ES/MINECO/MAT2013-46467-C4-3-R
000056081 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000056081 590__ $$a2.806$$b2016
000056081 591__ $$aMULTIDISCIPLINARY SCIENCES$$b15 / 63 = 0.238$$c2016$$dQ1$$eT1
000056081 592__ $$a1.236$$b2016
000056081 593__ $$aAgricultural and Biological Sciences (miscellaneous)$$c2016$$dQ1
000056081 593__ $$aMedicine (miscellaneous)$$c2016$$dQ1
000056081 593__ $$aBiochemistry, Genetics and Molecular Biology (miscellaneous)$$c2016$$dQ1
000056081 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000056081 700__ $$aArmengol, Monica
000056081 700__ $$aJ.Price, Andrew
000056081 700__ $$aA.Hulley, Philippa
000056081 700__ $$aS.Gill, Harinderjit
000056081 700__ $$0(orcid)0000-0001-8741-6452$$aDoblaré, Manuel$$uUniversidad de Zaragoza
000056081 700__ $$0(orcid)0000-0003-0088-7222$$aHamdy Doweidar, Mohamed$$uUniversidad de Zaragoza
000056081 7102_ $$15004$$2605$$aUniversidad de Zaragoza$$bDpto. Ingeniería Mecánica$$cÁrea Mec.Med.Cont. y Teor.Est.
000056081 773__ $$g11, 6 (2016), 0157967 [19p.]$$pPLoS One$$tPloS one$$x1932-6203
000056081 8564_ $$s13146029$$uhttps://zaguan.unizar.es/record/56081/files/texto_completo.pdf$$yVersión publicada
000056081 8564_ $$s103620$$uhttps://zaguan.unizar.es/record/56081/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000056081 909CO $$ooai:zaguan.unizar.es:56081$$particulos$$pdriver
000056081 951__ $$a2020-02-21-13:08:50
000056081 980__ $$aARTICLE