000056086 001__ 56086 000056086 005__ 20210121114531.0 000056086 0247_ $$2doi$$a10.3748/wjg.v21.i2.396 000056086 0248_ $$2sideral$$a89551 000056086 037__ $$aART-2015-89551 000056086 041__ $$aeng 000056086 100__ $$aBejaoui, M. 000056086 245__ $$aEmerging concepts in liver graft preservation 000056086 260__ $$c2015 000056086 5060_ $$aAccess copy available to the general public$$fUnrestricted 000056086 5203_ $$aThe urgent need to expand the donor pool in order to attend to the growing demand for liver transplantation has obliged physicians to consider the use of suboptimal liver grafts and also to redefine the preservation strategies. This review examines the different methods of liver graft preservation, focusing on the latest advances in both static cold storage and machine perfusion (MP). The new strategies for static cold storage are mainly designed to increase the fatty liver graft preservation via the supplementation of commercial organ preservation solutions with additives. In this paper we stress the importance of carrying out effective graft washout after static cold preservation, and present a detailed discussion of the future perspectives for dynamic graft preservation using MP at different temperatures (hypothermia at 4 °C, normothermia at 37 °C and subnormothermia at 20 °C-25 °C). Finally, we highlight some emerging applications of regenerative medicine in liver graft preservation. In conclusion, this review discusses the “state of the art” and future perspectives in static and dynamic liver graft preservation in order to improve graft viability. 000056086 536__ $$9info:eu-repo/grantAgreement/ES/FIS/PI12-00519 000056086 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc$$uhttp://creativecommons.org/licenses/by-nc/3.0/es/ 000056086 590__ $$a2.787$$b2015 000056086 591__ $$aGASTROENTEROLOGY & HEPATOLOGY$$b38 / 79 = 0.481$$c2015$$dQ2$$eT2 000056086 592__ $$a1.107$$b2015 000056086 593__ $$aMedicine (miscellaneous)$$c2015$$dQ1 000056086 593__ $$aGastroenterology$$c2015$$dQ1 000056086 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion 000056086 700__ $$aPantazi, E. 000056086 700__ $$aFolch-Puy, E. 000056086 700__ $$aBaptista, P.M. 000056086 700__ $$0(orcid)0000-0002-8275-7191$$aGarcía-Gil, A.$$uUniversidad de Zaragoza 000056086 700__ $$aAdam, R. 000056086 700__ $$aRoselló-Catafau, J. 000056086 7102_ $$11004$$2090$$aUniversidad de Zaragoza$$bDpto. Cirugía,Ginecol.Obstetr.$$cÁrea Cirugía 000056086 773__ $$g21, 2 (2015), 396-407$$tWorld Journal of Gastroenterology$$x1007-9327 000056086 8564_ $$s1146846$$uhttps://zaguan.unizar.es/record/56086/files/texto_completo.pdf$$yVersión publicada 000056086 8564_ $$s73824$$uhttps://zaguan.unizar.es/record/56086/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada 000056086 909CO $$ooai:zaguan.unizar.es:56086$$particulos$$pdriver 000056086 951__ $$a2021-01-21-11:10:22 000056086 980__ $$aARTICLE