doi:10.1016/j.ejpb.2015.08.007engGimeno, M.Pinczowski, P.Pérez Rontome, MartaGiorello, A.Martínez Barca, Miguel ÁngelSantamaría Ramiro, Jesús MarcosArruebo Gordo, ManuelLuján Lerma, LluisA controlled antibiotic release system to prevent orthopedic-implant associated infections: An in vitro studyART-2015-92007A new device for local delivery of antibiotics is presented, with potential use as a drug-eluting fixation pin for orthopedic applications. The implant consists of a stainless steel hollow tubular reservoir packed with the desired antibiotic. Release takes place through several orifices previously drilled in the reservoir wall, a process that does not compromise the mechanical properties required for the implant. Depending on the antibiotic chosen and the number of orifices, the release profile can be tailored from a rapid release of the load (ca. 20 h) to a combination of rapid initial release and slower, sustained release for a longer period of time (ca. 200 h). An excellent bactericidal action is obtained, with 4-log reductions achieved in as little as 2 h, and total bacterial eradication in 8 h using 6-pinholed implants filled with cefazolin.2015http://zaguan.unizar.es/record/5614210.1016/j.ejpb.2015.08.007http://zaguan.unizar.es/record/56142oai:zaguan.unizar.es:56142info:eu-repo/grantAgreement/EUR/FP7/ERC2013-CoG-614715EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS 96 (2015), 264-271by-nc-ndhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/info:eu-repo/semantics/openAccess