56142 20210121114459.0 doi 10.1016/j.ejpb.2015.08.007 sideral 92007 ART-2015-92007 eng Gimeno, M. A controlled antibiotic release system to prevent orthopedic-implant associated infections: An in vitro study 2015 Access copy available to the general public Unrestricted A new device for local delivery of antibiotics is presented, with potential use as a drug-eluting fixation pin for orthopedic applications. The implant consists of a stainless steel hollow tubular reservoir packed with the desired antibiotic. Release takes place through several orifices previously drilled in the reservoir wall, a process that does not compromise the mechanical properties required for the implant. Depending on the antibiotic chosen and the number of orifices, the release profile can be tailored from a rapid release of the load (ca. 20 h) to a combination of rapid initial release and slower, sustained release for a longer period of time (ca. 200 h). An excellent bactericidal action is obtained, with 4-log reductions achieved in as little as 2 h, and total bacterial eradication in 8 h using 6-pinholed implants filled with cefazolin. info:eu-repo/grantAgreement/EC/FP7/614715/EU/A Photo-triggered On-demand Drug Delivery System for Chronic Pain/NANOHEDONISM info:eu-repo/semantics/openAccess by-nc-nd http://creativecommons.org/licenses/by-nc-nd/3.0/es/ 3.975 2015 PHARMACOLOGY & PHARMACY 44 / 255 = 0.173 2015 Q1 T1 1.437 2015 Biotechnology 2015 Q1 Pharmaceutical Science 2015 Q1 Medicine (miscellaneous) 2015 Q1 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Pinczowski, P. (orcid)0000-0002-8133-2124 Pérez, M. Universidad de Zaragoza Giorello, A. (orcid)0000-0002-8375-0354 Martínez, M.Á. Universidad de Zaragoza (orcid)0000-0002-8701-9745 Santamaría, J. Universidad de Zaragoza (orcid)0000-0003-3165-0156 Arruebo, M. Universidad de Zaragoza (orcid)0000-0002-2053-9842 Luján, L. Universidad de Zaragoza 1001 025 Universidad de Zaragoza Dpto. Anatom.,Embri.Genét.Ani. Área Anatom.Anatom.Patológ.Com 1009 773 Universidad de Zaragoza Dpto. Patología Animal Área Sanidad Animal 5005 555 Universidad de Zaragoza Dpto. Ing.Quím.Tecnol.Med.Amb. Área Ingeniería Química 5004 605 Universidad de Zaragoza Dpto. Ingeniería Mecánica Área Mec.Med.Cont. y Teor.Est. 96 (2015), 264-271 Eur. j. pharm. biopharm. European Journal of Pharmaceutics and Biopharmaceutics 0939-6411 1218256 http://zaguan.unizar.es/record/56142/files/texto_completo.pdf Versión publicada 112776 http://zaguan.unizar.es/record/56142/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:56142 articulos driver 2021-01-21-10:50:10 ARTICLE