Deconvolution analysis for classifying gastric adenocarcinoma patients based on differential scanning calorimetry serum thermograms
Resumen: Recently, differential scanning calorimetry (DSC) has been acknowledged as a novel tool for diagnosing and monitoring several diseases. This highly sensitive technique has been traditionally used to study thermally induced protein folding/unfolding transitions. In previous research papers, DSC profiles from blood samples of patients were analyzed and they exhibited marked differences in the thermal denaturation profile. Thus, we investigated the use of this novel technology in blood serum samples from 25 healthy subjects and 30 patients with gastric adenocarcinoma (GAC) at different stages of tumor development with a new multiparametric approach. The analysis of the calorimetric profiles of blood serum from GAC patients allowed us to discriminate three stages of cancer development (I to III) from those of healthy individuals. After a multiparametric analysis, a classification of blood serum DSC parameters from patients with GAC is proposed. Certain parameters exhibited significant differences (P < 0.05) and allowed the discrimination of healthy subjects/patients from patients at different tumor stages. The results of this work validate DSC as a novel technique for GAC patient classification and staging, and offer new graphical tools and value ranges for the acquired parameters in order to discriminate healthy from diseased subjects with increased disease burden.
Idioma: Inglés
DOI: 10.1038/srep07988
Año: 2015
Publicado en: Scientific Reports 5 (2015), 07988 [8 p.]
ISSN: 2045-2322

Factor impacto JCR: 5.228 (2015)
Categ. JCR: MULTIDISCIPLINARY SCIENCES rank: 7 / 62 = 0.113 (2015) - Q1 - T1
Factor impacto SCIMAGO: 2.034 - Multidisciplinary (Q1)

Financiación: info:eu-repo/grantAgreement/ES/MICINN/BFU2010-19451
Financiación: info:eu-repo/grantAgreement/ES/MICINN/PTA2009-2341-I
Tipo y forma: Article (PostPrint)
Área (Departamento): Area Medicina (Dpto. Medicina, Psiqu. y Derm.)
Área (Departamento): Área Bioquímica y Biolog.Mole. (Dpto. Bioq.Biolog.Mol. Celular)

Creative Commons You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.

Exportado de SIDERAL (2021-01-21-11:17:48)

Este artículo se encuentra en las siguientes colecciones:

 Record created 2016-07-21, last modified 2021-01-21

Rate this document:

Rate this document:
(Not yet reviewed)