000056264 001__ 56264
000056264 005__ 20210121114531.0
000056264 0247_ $$2doi$$a10.1186/s12711-015-0141-5
000056264 0248_ $$2sideral$$a91684
000056264 037__ $$aART-2015-91684
000056264 041__ $$aeng
000056264 100__ $$0(orcid)0000-0001-6256-5478$$aVarona, L.$$uUniversidad de Zaragoza
000056264 245__ $$aConsequences of paternally inherited effects on the genetic evaluation of maternal effects
000056264 260__ $$c2015
000056264 5060_ $$aAccess copy available to the general public$$fUnrestricted
000056264 5203_ $$aBackground: Mixed models are commonly used for the estimation of variance components and genetic evaluation of livestock populations. Some evaluation models include two types of additive genetic effects, direct and maternal. Estimates of variance components obtained with models that account for maternal effects have been the subject of a long-standing controversy about strong negative estimates of the covariance between direct and maternal effects. Genomic imprinting is known to be in some cases statistically confounded with maternal effects. In this study, we analysed the consequences of ignoring paternally inherited effects on the partitioning of genetic variance.
Results: We showed that the existence of paternal parent-of-origin effects can bias the estimation of variance components when maternal effects are included in the evaluation model. Specifically, we demonstrated that adding a constraint on the genetic parameters of a maternal model resulted in correlations between relatives that were the same as those obtained with a model that fits only paternally inherited effects for most pairs of individuals, as in livestock pedigrees. The main consequence is an upward bias in the estimates of the direct and maternal additive genetic variances and a downward bias in the direct-maternal genetic covariance. This was confirmed by a simulation study that investigated five scenarios, with the trait affected by (1) only additive genetic effects, (2) only paternally inherited effects, (3) additive genetic and paternally inherited effects, (4) direct and maternal additive genetic effects and (5) direct and maternal additive genetic plus paternally inherited effects. For each scenario, the existence of a paternally inherited effect not accounted for by the estimation model resulted in a partitioning of the genetic variance according to the predicted pattern. In addition, a model comparison test confirmed that direct and maternal additive models and paternally inherited models provided an equivalent fit.
Conclusions: Ignoring paternally inherited effects in the maternal models for genetic evaluation can lead to a specific pattern of bias in variance component estimates, which may account for the unexpectedly strong negative direct-maternal genetic correlations that are typically reported in the literature.
000056264 536__ $$9info:eu-repo/grantAgreement/ES/MINECO/AGL2010-15903$$9info:eu-repo/grantAgreement/ES/DGA/A51
000056264 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000056264 590__ $$a2.895$$b2015
000056264 591__ $$aAGRICULTURE, DAIRY & ANIMAL SCIENCE$$b2 / 58 = 0.034$$c2015$$dQ1$$eT1
000056264 591__ $$aGENETICS & HEREDITY$$b69 / 166 = 0.416$$c2015$$dQ2$$eT2
000056264 592__ $$a1.428$$b2015
000056264 593__ $$aAnimal Science and Zoology$$c2015$$dQ1
000056264 593__ $$aMedicine (miscellaneous)$$c2015$$dQ1
000056264 593__ $$aEcology, Evolution, Behavior and Systematics$$c2015$$dQ1
000056264 593__ $$aGenetics$$c2015$$dQ2
000056264 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000056264 700__ $$aMunilla, S.$$uUniversidad de Zaragoza
000056264 700__ $$aCasellas, J.
000056264 700__ $$0(orcid)0000-0002-1946-1187$$aMoreno, C.$$uUniversidad de Zaragoza
000056264 700__ $$0(orcid)0000-0002-3042-2250$$aAltarriba, J.$$uUniversidad de Zaragoza
000056264 7102_ $$11001$$2420$$aUniversidad de Zaragoza$$bDpto. Anatom.,Embri.Genét.Ani.$$cÁrea Genética
000056264 773__ $$g47, 1 (2015), 63 [13 pp]$$pGenet. sel. evol.$$tGENETICS SELECTION EVOLUTION$$x0999-193X
000056264 8564_ $$s537747$$uhttps://zaguan.unizar.es/record/56264/files/texto_completo.pdf$$yVersión publicada
000056264 8564_ $$s114171$$uhttps://zaguan.unizar.es/record/56264/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000056264 909CO $$ooai:zaguan.unizar.es:56264$$particulos$$pdriver
000056264 951__ $$a2021-01-21-11:10:37
000056264 980__ $$aARTICLE