000056325 001__ 56325 000056325 005__ 20200221144212.0 000056325 0247_ $$2doi$$a10.1186/s13073-016-0323-y 000056325 0248_ $$2sideral$$a95608 000056325 037__ $$aART-2016-95608 000056325 041__ $$aeng 000056325 100__ $$aAuffray, C. 000056325 245__ $$aMaking sense of big data in health research: Towards an EU action plan 000056325 260__ $$c2016 000056325 5060_ $$aAccess copy available to the general public$$fUnrestricted 000056325 5203_ $$aMedicine and healthcare are undergoing profound changes. Whole-genome sequencing and high-resolution imaging technologies are key drivers of this rapid and crucial transformation. Technological innovation combined with automation and miniaturization has triggered an explosion in data production that will soon reach exabyte proportions. How are we going to deal with this exponential increase in data production? The potential of “big data” for improving health is enormous but, at the same time, we face a wide range of challenges to overcome urgently. Europe is very proud of its cultural diversity; however, exploitation of the data made available through advances in genomic medicine, imaging, and a wide range of mobile health applications or connected devices is hampered by numerous historical, technical, legal, and political barriers. European health systems and databases are diverse and fragmented. There is a lack of harmonization of data formats, processing, analysis, and data transfer, which leads to incompatibilities and lost opportunities. Legal frameworks for data sharing are evolving. Clinicians, researchers, and citizens need improved methods, tools, and training to generate, analyze, and query data effectively. Addressing these barriers will contribute to creating the European Single Market for health, which will improve health and healthcare for all Europeans. 000056325 536__ $$9This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 664691-BRIDGEHealth$$9info:eu-repo/grantAgreement/EC/H2020/664691/EU/BRidging Information and Data Generation for Evidence-based Health policy and research/BRIDGEHealth$$9This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 644753-KConnect$$9info:eu-repo/grantAgreement/EC/H2020/644753/EU/Khresmoi Multilingual Medical Text Analysis, Search and Machine Translation Connected in a Thriving Data-Value Chain/KConnect$$9This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 634143-MedBioinformatics$$9info:eu-repo/grantAgreement/EC/H2020/634143/EU/Creating medically-driven integrative bioinformatics applications focused on oncology, CNS disorders and their comorbidities (MedBioinformatics)/MedBioinformatics 000056325 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/ 000056325 590__ $$a7.071$$b2016 000056325 591__ $$aGENETICS & HEREDITY$$b13 / 166 = 0.078$$c2016$$dQ1$$eT1 000056325 592__ $$a3.966$$b2016 000056325 593__ $$aGenetics$$c2016$$dQ1 000056325 593__ $$aMolecular Medicine$$c2016$$dQ1 000056325 593__ $$aMolecular Biology$$c2016$$dQ1 000056325 593__ $$aGenetics (clinical)$$c2016$$dQ1 000056325 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion 000056325 700__ $$aBalling, R. 000056325 700__ $$aBarroso, I. 000056325 700__ $$aBencze, L. 000056325 700__ $$aBenson, M. 000056325 700__ $$aBergeron, J. 000056325 700__ $$0(orcid)0000-0002-0961-3298$$aBernal-Delgado, E. 000056325 700__ $$aBlomberg, N. 000056325 700__ $$aBock, C. 000056325 700__ $$aConesa, A. 000056325 700__ $$aDel Signore, S. 000056325 700__ $$aDelogne, C. 000056325 700__ $$aDevilee, P. 000056325 700__ $$aDi Meglio, A. 000056325 700__ $$aEijkemans, M. 000056325 700__ $$aFlicek, P. 000056325 700__ $$aGraf, N. 000056325 700__ $$aGrimm, V. 000056325 700__ $$aGuchelaar, H.J 000056325 700__ $$aGuo, Y.K 000056325 700__ $$aGut, I.G. 000056325 700__ $$aHanbury, A. 000056325 700__ $$aHanif, S. 000056325 700__ $$aHilgers, R.D 000056325 700__ $$aHonrado 000056325 700__ $$aHose, D.R. 000056325 700__ $$aHouwing-Duistermaat, J. 000056325 700__ $$aHubbard, T. 000056325 700__ $$aJanacek, S.H. 000056325 700__ $$aKaranikas, H. 000056325 700__ $$aKievits, T. 000056325 700__ $$aKohler, M. 000056325 700__ $$aKremer, A. 000056325 700__ $$aLanfear, J. 000056325 700__ $$aLengauer, T. 000056325 700__ $$aMaes, E. 000056325 700__ $$aMeert, T. 000056325 700__ $$aMüller, W. 000056325 700__ $$aNickel, D. 000056325 700__ $$aOledzki, P. 000056325 700__ $$aPedersen, B. 000056325 700__ $$aPetkovic, M. 000056325 700__ $$aPliakos, K. 000056325 700__ $$aRattray, M. 000056325 700__ $$ai Màs, J.R. 000056325 700__ $$aSchneider, R. 000056325 700__ $$aSengstag, T. 000056325 700__ $$aSerra-Picamal, X. 000056325 700__ $$aSpek, W. 000056325 700__ $$aVaas, L.A.I. 000056325 700__ $$avan Batenburg, O. 000056325 700__ $$aVandelaer, M. 000056325 700__ $$aVarnai, P. 000056325 700__ $$aVilloslada, P. 000056325 700__ $$aVizcaíno, J.A. 000056325 700__ $$aWubbe, J.P.M. 000056325 700__ $$aZanetti, G. 000056325 773__ $$g8, 71 (2016), [13 pp.]$$pGenome medicine$$tGenome medicine$$x1756-994X 000056325 8564_ $$s1525785$$uhttps://zaguan.unizar.es/record/56325/files/texto_completo.pdf$$yVersión publicada 000056325 8564_ $$s99675$$uhttps://zaguan.unizar.es/record/56325/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada 000056325 909CO $$ooai:zaguan.unizar.es:56325$$particulos$$pdriver 000056325 951__ $$a2020-02-21-13:12:25 000056325 980__ $$aARTICLE