56334 20200221144335.0 doi 10.2147/IJN.S108812 sideral 95654 ART-2016-95654 eng (orcid)0000-0002-6256-742X Ortiz de Solorzano, I.. Universidad de Zaragoza Continuous synthesis of drug-loaded nanoparticles using microchannel emulsification and numerical modeling: Effect of passive mixing 2016 Access copy available to the general public Unrestricted By using interdigital microfluidic reactors, monodisperse poly(d, l lactic-co-glycolic acid) nanoparticles (NPs) can be produced in a continuous manner and at a large scale (~10 g/h). An optimized synthesis protocol was obtained by selecting the appropriated passive mixer and fluid flow conditions to produce monodisperse NPs. A reduced NP polydispersity was obtained when using the microfluidic platform compared with the one obtained with NPs produced in a conventional discontinuous batch reactor. Cyclosporin, an immunosuppressant drug, was used as a model to validate the efficiency of the microfluidic platform to produce drug-loaded monodisperse poly(d, l lactic-co-glycolic acid) NPs. The influence of the mixer geometries and temperatures were analyzed, and the experimental results were corroborated by using computational fluid dynamic three-dimensional simulations. Flow patterns, mixing times, and mixing efficiencies were calculated, and the model supported with experimental results. The progress of mixing in the interdigital mixer was quantified by using the volume fractions of the organic and aqueous phases used during the emulsification–evaporation process. The developed model and methods were applied to determine the required time for achieving a complete mixing in each microreactor at different fluid flow conditions, temperatures, and mixing rates. info:eu-repo/grantAgreement/EC/FP7/614715/EU/A Photo-triggered On-demand Drug Delivery System for Chronic Pain/NANOHEDONISM info:eu-repo/semantics/openAccess by-nc http://creativecommons.org/licenses/by-nc/3.0/es/ 4.3 2016 PHARMACOLOGY & PHARMACY 37 / 256 = 0.145 2016 Q1 T1 NANOSCIENCE & NANOTECHNOLOGY 29 / 87 = 0.333 2016 Q2 T2 1.173 2016 Bioengineering 2016 Q1 Biomaterials 2016 Q1 Biophysics 2016 Q1 Organic Chemistry 2016 Q1 Medicine (miscellaneous) 2016 Q1 Drug Discovery 2016 Q1 Nanoscience and Nanotechnology 2016 Q2 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion (orcid)0000-0002-4678-7465 Uson, L. (orcid)0000-0002-6277-7996 Larrea, A. Universidad de Zaragoza (orcid)0000-0002-1002-1396 Miana, M. Universidad de Zaragoza (orcid)0000-0002-6873-5244 Sebastian, V. Universidad de Zaragoza (orcid)0000-0003-3165-0156 Arruebo, M. Universidad de Zaragoza 5005 555 Universidad de Zaragoza Dpto. Ing.Quím.Tecnol.Med.Amb. Área Ingeniería Química 5004 590 Universidad de Zaragoza Dpto. Ingeniería Mecánica Área Máquinas y Motores Térmi. 11 (2016), 3397-3416 Int. j. nanomed. International Journal of Nanomedicine 1176-9114 15784365 http://zaguan.unizar.es/record/56334/files/texto_completo.pdf Versión publicada 45367 http://zaguan.unizar.es/record/56334/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:56334 articulos driver 2020-02-21-13:46:54 ARTICLE