000056675 001__ 56675
000056675 005__ 20220831095640.0
000056675 0247_ $$2doi$$a10.1371/journal.pone.0157293
000056675 0248_ $$2sideral$$a95781
000056675 037__ $$aART-2016-95781
000056675 041__ $$aeng
000056675 100__ $$0(orcid)0000-0002-1609-5994$$aSatue, M.
000056675 245__ $$aRelationship between visual dysfunction and retinal changes in patients with multiple sclerosis.
000056675 260__ $$c2016
000056675 5060_ $$aAccess copy available to the general public$$fUnrestricted
000056675 5203_ $$aAim
To evaluate structural changes in the retina and their correlation with visual dysfunction in patients with multiple sclerosis.
Methods
Patients with multiple sclerosis (n = 84) and healthy controls (n = 84) underwent structural eval- uation of the retinal nerve fiber layer, and macular and ganglion cell layer thicknesses using Spectral domain optical coherence tomography (SD-OCT). All subjects underwent high and low contrast visual acuity, color vision (using the Farnsworth and L ´Anthony desaturated D15 color tests), and contrast sensitivity vision using the Pelli Robson chart and CSV 1000E test.
Results
Macular, retinal nerve fiber layer, and ganglion cell layer thinning was observed in multiple sclerosis patients compared to healthy controls (p<0.05). High- and low-contrast visual acu- ity and contrast sensitivity vision at four different spatial frequencies were significantly reduced in comparison with healthy subjects (p<0.05). Macular, retinal nerve fiber layer and ganglion cell layer measurements correlated with high and low contrast visual acuity, and contrast sensitivity vision. Contrast sensitivity vision was the functional parameter that most strongly correlated with the structural measurements in multiple sclerosis and was associ- ated with ganglion cell layer measurements. The L ´Anthony color vision score (age-cor- rected color confusion index) was associated with macular measurements.
Conclusions
Patients with multiple sclerosis had visual dysfunction that correlated with structural changes evaluated by SD-OCT. Macular and ganglion cell layer measurements may be good indicators of visual impairment in multiple sclerosis patients.
000056675 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000056675 590__ $$a2.806$$b2016
000056675 591__ $$aMULTIDISCIPLINARY SCIENCES$$b15 / 63 = 0.238$$c2016$$dQ1$$eT1
000056675 592__ $$a1.236$$b2016
000056675 593__ $$aAgricultural and Biological Sciences (miscellaneous)$$c2016$$dQ1
000056675 593__ $$aMedicine (miscellaneous)$$c2016$$dQ1
000056675 593__ $$aBiochemistry, Genetics and Molecular Biology (miscellaneous)$$c2016$$dQ1
000056675 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000056675 700__ $$aRodrigo, MJ.
000056675 700__ $$0(orcid)0000-0002-6591-0801$$aOtin, S.$$uUniversidad de Zaragoza
000056675 700__ $$0(orcid)0000-0001-5320-7839$$aBambo, MP.
000056675 700__ $$0(orcid)0000-0002-4316-1635$$aFuertes, MI.$$uUniversidad de Zaragoza
000056675 700__ $$0(orcid)0000-0002-9788-2083$$aAra, JR.
000056675 700__ $$aMartin, J.
000056675 700__ $$0(orcid)0000-0002-1402-3129$$aPolo, V.$$uUniversidad de Zaragoza
000056675 700__ $$0(orcid)0000-0002-6745-7668$$aLarrosa, JM.$$uUniversidad de Zaragoza
000056675 700__ $$0(orcid)0000-0003-2389-8282$$aPablo, L.$$uUniversidad de Zaragoza
000056675 700__ $$0(orcid)0000-0001-6258-2489$$aGarcia-Martin, E.$$uUniversidad de Zaragoza
000056675 7102_ $$11004$$2646$$aUniversidad de Zaragoza$$bDpto. Cirugía,Ginecol.Obstetr.$$cÁrea Oftalmología
000056675 7102_ $$12002$$2647$$aUniversidad de Zaragoza$$bDpto. Física Aplicada$$cÁrea Óptica
000056675 773__ $$g11, 6 (2016), 0157293 [14 p.]$$pPLoS One$$tPLoS ONE$$x1932-6203
000056675 8564_ $$s869981$$uhttps://zaguan.unizar.es/record/56675/files/texto_completo.pdf$$yVersión publicada
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000056675 951__ $$a2022-08-31-09:47:59
000056675 980__ $$aARTICLE