56738 20210303162448.0 doi 10.1371/journal.pone.0159136 sideral 96002 ART-2016-96002 eng Jiménez, S. Rosa canina extracts have antiproliferative and antioxidant effects on caco-2 human colon cancer 2016 Access copy available to the general public Unrestricted The in vitro antiproliferative and antioxidant effects of different fractions of Rosa canina hips on human colon cancer cell lines (Caco-2) was studied. The compounds tested were total extract (fraction 1), vitamin C (fraction 2), neutral polyphenols (fraction 3) and acidic polyphenols (fraction 4). All the extracts showed high cytotoxicity after 72 h, both low and high concentrations. The flow cytometric analysis revealed that all the fractions produce disturbances in the cell cycle resulting in a concomitant cell death by an apoptotic pathway. Changes in the redox status of Caco-2 cells in response to Rosa canina hips were determined. Cells were exposed to hydrogen peroxide in presence of plant fractions and the production of Reactive Oxygen Species (ROS) was significantly decreased. Therefore, our data demonstrate that rosehip extracts are a powerful antioxidant that produces an antiproliferative effect in Caco-2 cells. Therefore, these results predict a promising future for Rosa canina as a therapeutic agent. Thus, this natural plant could be an effective component of functional foods addressed towards colorectal carcinoma. info:eu-repo/grantAgreement/ES/MINECO/SAF2013-41651-R info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 2.806 2016 MULTIDISCIPLINARY SCIENCES 15 / 63 = 0.238 2016 Q1 T1 1.236 2016 Agricultural and Biological Sciences (miscellaneous) 2016 Q1 Medicine (miscellaneous) 2016 Q1 Biochemistry, Genetics and Molecular Biology (miscellaneous) 2016 Q1 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Gascón, S. Luquin, A. (orcid)0000-0002-5801-3352 Laguna, M. Ancin-Azpilicueta, C. (orcid)0000-0002-3595-7668 Rodríguez-Yoldi, M.J. Universidad de Zaragoza 1005 410 Universidad de Zaragoza Dpto. Farmacología y Fisiolog. Área Fisiología 11, 7 (2016), 0159136 [14p.] PLoS One PloS one 1932-6203 790748 http://zaguan.unizar.es/record/56738/files/texto_completo.pdf Versión publicada 104979 http://zaguan.unizar.es/record/56738/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:56738 articulos driver 2021-03-03-16:11:04 ARTICLE