000056745 001__ 56745
000056745 005__ 20200221144327.0
000056745 0247_ $$2doi$$a10.1186/s12863-016-0405-2
000056745 0248_ $$2sideral$$a96106
000056745 037__ $$aART-2016-96106
000056745 041__ $$aeng
000056745 100__ $$aSánchez-Molano, E.
000056745 245__ $$aA practical approach to detect ancestral haplotypes in livestock populations
000056745 260__ $$c2016
000056745 5060_ $$aAccess copy available to the general public$$fUnrestricted
000056745 5203_ $$aBackground: The effects of different evolutionary forces are expected to lead to the conservation, over many generations, of particular genomic regions (haplotypes) due to the development of linkage disequilibrium (LD). The detection and identification of early (ancestral) haplotypes can be used to clarify the evolutionary dynamics of different populations as well as identify selection signatures and genomic regions of interest to be used both in conservation and breeding programs. The aims of this study were to develop a simple procedure to identify ancestral haplotypes segregating across several generations both within and between populations with genetic links based on whole-genome scanning. This procedure was tested with simulated and then applied to real data from different genotyped populations of Spanish, Fleckvieh, Simmental and Brown-Swiss cattle.Results: The identification of ancestral haplotypes has shown coincident patterns of selection across different breeds, allowing the detection of common regions of interest on different bovine chromosomes and mirroring the evolutionary dynamics of the studied populations. These regions, mainly located on chromosomes BTA5, BTA6, BTA7 and BTA21 are related with certain animal traits such as coat colour and milk protein and fat content.Conclusion: In agreement with previous studies, the detection of ancestral haplotypes provides useful information for the development and comparison of breeding and conservation programs both through the identification of selection signatures and other regions of interest, and as indicator of the general genetic status of the populations.
000056745 536__ $$9info:eu-repo/grantAgreement/ES/MINECO/AGL2010-15903$$9info:eu-repo/grantAgreement/EC/FP7/289592/EU/Next generation European system for cattle improvement and management/GENE2FARM
000056745 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000056745 590__ $$a2.266$$b2016
000056745 591__ $$aGENETICS & HEREDITY$$b95 / 166 = 0.572$$c2016$$dQ3$$eT2
000056745 592__ $$a1.159$$b2016
000056745 593__ $$aGenetics$$c2016$$dQ2
000056745 593__ $$aGenetics (clinical)$$c2016$$dQ3
000056745 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000056745 700__ $$aTsiokos, D.
000056745 700__ $$aChatziplis, D.
000056745 700__ $$aJorjani, H.
000056745 700__ $$aDegano, L.
000056745 700__ $$aDiaz, C.
000056745 700__ $$aRossoni, A.
000056745 700__ $$aSchwarzenbacher, H.
000056745 700__ $$aSeefried, F.
000056745 700__ $$0(orcid)0000-0001-6256-5478$$aVarona, L.$$uUniversidad de Zaragoza
000056745 700__ $$aVicario, D.
000056745 700__ $$aNicolazzi, E.L.
000056745 700__ $$aBanos, G.
000056745 7102_ $$11001$$2420$$aUniversidad de Zaragoza$$bDpto. Anatom.,Embri.Genét.Ani.$$cÁrea Genética
000056745 773__ $$g17, 1 (2016), 91 [11 pp.]$$pBMC Genet.$$tBMC GENETICS$$x1471-2156
000056745 8564_ $$s758812$$uhttps://zaguan.unizar.es/record/56745/files/texto_completo.pdf$$yVersión publicada
000056745 8564_ $$s103183$$uhttps://zaguan.unizar.es/record/56745/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000056745 909CO $$ooai:zaguan.unizar.es:56745$$particulos$$pdriver
000056745 951__ $$a2020-02-21-13:44:25
000056745 980__ $$aARTICLE