000056794 001__ 56794
000056794 005__ 20220120225830.0
000056794 0247_ $$2doi$$a10.2147/CIA.S108072
000056794 0248_ $$2sideral$$a96309
000056794 037__ $$aART-2016-96309
000056794 041__ $$aeng
000056794 100__ $$aGimeno-Gracia, M.
000056794 245__ $$aPolypharmacy in older adults with human immunodeficiency virus infection compared with the general population
000056794 260__ $$c2016
000056794 5060_ $$aAccess copy available to the general public$$fUnrestricted
000056794 5203_ $$aBackground: The percentage of older HIV-positive patients is growing, with an increase in age-related comorbidities and concomitant medication. Objectives: To quantify polypharmacy and profile types of non-antiretroviral drugs collected at community pharmacies in 2014 by HIV-positive individuals on antiretroviral therapy and to compare these findings with those of the general population. Methods: HIV-positive patients (n=199) were compared with a group of patients from the general population (n=8, 172), aged between 50 and 64 years. The factors compared were prevalence of polypharmacy (=5 comedications with cumulative defined daily dose DDD] per drug over 180), percentage of patients who collected each therapeutic class of drug, and median duration for each drug class (based on DDD). Results were stratified by sex. Results: Polypharmacy was more common in HIV-positive males than in the male general population (8.9% vs 4.4%, P=0.010). Polypharmacy was also higher in HIV-positive females than in the female general population (11.3% vs 3.4%, P=0.002). Percentage of HIV-positive patients receiving analgesics, anti-infectives, gastrointestinal drugs, central nervous system (CNS) agents, and respiratory drugs was higher than in the general population, with significant differences between male populations. No differences were observed in proportion of patients receiving cardiovascular drugs. The estimated number of treatment days (median DDDs) were higher in HIV-positive males than in males from the general population for anti-infectives (32.2 vs 20.0, P<0.001) and CNS agents (238.7 vs 120.0, P=0.002). A higher percentage of HIV-positive males than males from the general population received sulfonamides (17.1% vs 1.5%, P, 0.001), macrolides (37.1% vs 24.9%, P=0.020), and quinolones (34.3% vs 21.2%, P=0.009). Conclusion: Polypharmacy is more common in HIV-positive older males and females than in similarly aged members of the general population. HIV-positive patients received more CNS drugs and anti-infectives, specifically sulfonamides, macrolides, and quinolones, but there were no differences in the percentage of patients receiving cardiovascular drugs. It is essential to investigate nonantiretroviral therapy medication use in the HIV-positive population to ensure these patients receive appropriate management.
000056794 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc$$uhttp://creativecommons.org/licenses/by-nc/3.0/es/
000056794 590__ $$a2.581$$b2016
000056794 591__ $$aGERIATRICS & GERONTOLOGY$$b25 / 49 = 0.51$$c2016$$dQ3$$eT2
000056794 592__ $$a1.086$$b2016
000056794 593__ $$aMedicine (miscellaneous)$$c2016$$dQ1
000056794 593__ $$aGeriatrics and Gerontology$$c2016$$dQ1
000056794 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000056794 700__ $$aCrusells-Canales, M.
000056794 700__ $$aArmesto-Gómez, F.J.
000056794 700__ $$aCompaired-Turlán, V.
000056794 700__ $$0(orcid)0000-0002-6671-5661$$aRabanaque-Hernández, M.J.$$uUniversidad de Zaragoza
000056794 7102_ $$11008$$2615$$aUniversidad de Zaragoza$$bDpto. Microb.Med.Pr.,Sal.Públ.$$cÁrea Medic.Prevent.Salud Públ.
000056794 773__ $$g11 (2016), 1149-1157$$pClin. interv. aging$$tClinical Interventions in Aging$$x1176-9092
000056794 8564_ $$s629308$$uhttps://zaguan.unizar.es/record/56794/files/texto_completo.pdf$$yVersión publicada
000056794 8564_ $$s50543$$uhttps://zaguan.unizar.es/record/56794/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000056794 909CO $$ooai:zaguan.unizar.es:56794$$particulos$$pdriver
000056794 951__ $$a2022-01-20-22:54:08
000056794 980__ $$aARTICLE