000056800 001__ 56800
000056800 005__ 20200221144341.0
000056800 0247_ $$2doi$$a10.1186/s12966-016-0424-4
000056800 0248_ $$2sideral$$a96360
000056800 037__ $$aART-2016-96360
000056800 041__ $$aeng
000056800 100__ $$aPeplies, J.
000056800 245__ $$aLongitudinal associations of lifestyle factors and weight status with insulin resistance (HOMA-IR) in preadolescent children: The large prospective cohort study IDEFICS
000056800 260__ $$c2016
000056800 5060_ $$aAccess copy available to the general public$$fUnrestricted
000056800 5203_ $$aBackground: This study investigates prospective associations of anthropometrical and lifestyle indices with insulin resistance (IR) in European children from the IDEFICS cohort. Insulin resistance (IR) is a growing concern in childhood obesity and a central aspect of the metabolic syndrome (MS). It most likely represents the link between obesity and type 2 diabetes. Methods: This longitudinal study included 3348 preadolescent children aged 3 to 10.9 years from 8 European countries who were observed from 2007/2008 to 2009/2010. The main outcome measure in the present analysis is HOMA-IR (homeostasis model assessment as a common proxy indicator to quantify IR) at follow-up and in its longitudinal development. Anthropometrical measures and lifestyle indices, including objectively determined physical activity, were considered, among others factors, as determinants of IR. Prospective associations between IR at follow-up and anthropometrical and lifestyle indices were estimated by logistic regression models. Results: Country-specific prevalence rates of IR in the IDEFICS cohort of European children showed a positive trend with weight category. Prospective multivariate analyses showed the strongest positive associations of IR with BMI z-score (OR = 2.6 for unit change from the mean, 95 % CI 2.1-3.1) and z-score of waist circumference (OR = 2.2 for unit change from the mean, 95 % CI 1.9-2.6), which were analysed in separate models, but also for sex (OR = 2.2 for girls vs. boys, 95 % CI 1.5-3.1 up to OR 2.5, 95 % CI 1.8-3.6 depending on the model), audio-visual media time (OR = 1.2 for an additional hour per day, 95 % CI 1.0-1.4 in both models) and an inverse association of objectively determined physical activity (OR = 0.5 for 3rd compared to 1st quartile, 95 % CI 0.3-0.9 in both models). A longitudinal reduction of HOMA-IR was accompanied with a parallel decline in BMI. Conclusions: This study is, to our knowledge, the first prospective study on IR in a preadolescent children''s population. It supports the common hypothesis that overweight and obesity are the main determinants of IR. Our data also indicate that physical inactivity and a sedentary lifestyle are likewise associated with the development of IR, independent of weight status. The promotion of physical activity should thus be considered as an equal option to dietary intervention for the treatment of IR in the paediatric practice.
000056800 536__ $$9info:eu-repo/grantAgreement/EUR/FP6/FOOD-016181
000056800 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000056800 590__ $$a4.396$$b2016
000056800 591__ $$aPHYSIOLOGY$$b11 / 84 = 0.131$$c2016$$dQ1$$eT1
000056800 591__ $$aNUTRITION & DIETETICS$$b13 / 81 = 0.16$$c2016$$dQ1$$eT1
000056800 592__ $$a2.583$$b2016
000056800 593__ $$aMedicine (miscellaneous)$$c2016$$dQ1
000056800 593__ $$aPhysical Therapy, Sports Therapy and Rehabilitation$$c2016$$dQ1
000056800 593__ $$aNutrition and Dietetics$$c2016$$dQ1
000056800 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000056800 700__ $$aBörnhorst, C.
000056800 700__ $$aGünther, K.
000056800 700__ $$aFraterman, A.
000056800 700__ $$aRusso, P.
000056800 700__ $$aVeidebaum, T.
000056800 700__ $$aTornaritis, M.
000056800 700__ $$aDe Henauw, S.
000056800 700__ $$aMarild, S.
000056800 700__ $$aMolnar, D.
000056800 700__ $$0(orcid)0000-0003-0454-653X$$aMoreno, L.A.$$uUniversidad de Zaragoza
000056800 700__ $$aAhrens, W.
000056800 7102_ $$11006$$2255$$aUniversidad de Zaragoza$$bDpto. Fisiatría y Enfermería$$cÁrea Enfermería
000056800 773__ $$g13, 1 (2016), [12 pp]$$pInternational Journal of Behavioral Nutrition and Physical Activity$$tInternational Journal of Behavioral Nutrition and Physical Activity$$x1479-5868
000056800 8564_ $$s529085$$uhttps://zaguan.unizar.es/record/56800/files/texto_completo.pdf$$yVersión publicada
000056800 8564_ $$s80806$$uhttps://zaguan.unizar.es/record/56800/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000056800 909CO $$ooai:zaguan.unizar.es:56800$$particulos$$pdriver
000056800 951__ $$a2020-02-21-13:50:10
000056800 980__ $$aARTICLE