Glucose-functionalized Au nanoprisms for optoacoustic imaging and near-infrared photothermal therapy
Financiación FP7 / Fp7 Funds
Resumen: Targeted imaging and tumor therapy using nanomaterials has stimulated research interest recently, but the high cytotoxicity and low cellular uptake of nanomaterials limit their bioapplication. In this paper, glucose (Glc) was chosen to functionalize Au nanoprisms (NPrs) for improving the cytotoxicity and cellular uptake of Au@PEG-Glc NPrs into cancer cells. Glucose is a primary source of energy at the cellular level and at cellular membranes for cell recognition. A coating of glucose facilitates the accumulation of Au@PEG-Glc NPrs in a tumor region much more than Au@PEG NPrs. Due to the high accumulation and excellent photoabsorbing property of Au@PEG-Glc NPrs, enhanced optoacoustic imaging of a tumor in vivo was achieved, and visualization of the tumor further guided cancer treatment. Based on the optical-thermal conversion performance of Au@PEG-Glc NPrs, the tumor in vivo was effectively cured through photothermal therapy. The current work demonstrates the great potential of Au@PEG-Glc NPrs in optoacoustic imaging and photothermal cancer therapy in future.
Idioma: Inglés
DOI: 10.1039/c5nr06261f
Año: 2016
Publicado en: NANOSCALE 8, 1 (2016), 492-499
ISSN: 2040-3364

Factor impacto JCR: 7.367 (2016)
Categ. JCR: MATERIALS SCIENCE, MULTIDISCIPLINARY rank: 23 / 275 = 0.084 (2016) - Q1 - T1
Categ. JCR: NANOSCIENCE & NANOTECHNOLOGY rank: 13 / 87 = 0.149 (2016) - Q1 - T1
Categ. JCR: CHEMISTRY, MULTIDISCIPLINARY rank: 21 / 166 = 0.127 (2016) - Q1 - T1
Categ. JCR: PHYSICS, APPLIED rank: 13 / 147 = 0.088 (2016) - Q1 - T1

Factor impacto SCIMAGO: 2.789 - Nanoscience and Nanotechnology (Q1) - Materials Science (miscellaneous) (Q1)

Financiación: info:eu-repo/grantAgreement/EC/FP7/239931/EU/Multifunctional Magnetic Nanoparticles: Towards Smart Drugs Design/NANOPUZZLE
Tipo y forma: Article (Published version)
Área (Departamento): Área Química Orgánica (Dpto. Química Orgánica)

Creative Commons You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.


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