Opposite cannabis-cognition associations in psychotic patients depending on family history

González-Pinto, A. ; González-Ortega, I. ; Alberich, S. ; De Azúa, S.R. ; Bernardo, M. ; Bioque, M. ; Cabrera, B. ; Corripio, I. ; Arango, C. ; Lobo, A. (Universidad de Zaragoza) ; Sánchez-Torres, A.M. ; Cuesta, M.J. ; Ugarte, A. ; Fernández, M. ; Mezquida, G. ; Meseguer, A. ; Vieta, E. ; Torrent, C. ; Contreras, F. ; Albacete, A. ; Alonso-Solís, A. ; Rabella, M. ; Moreno-Izco, L. ; Usall, J. ; Butjosa, A. ; Ibáñez, Á. ; Bobes, J. ; Al-Halabí, S. ; Zapata-Usábel, M.T. ; Laporta-Herrero, I. ; Balanzá-Martínez, V. ; Bergé, D. ; Mané, A. ; Rodriguez-Jimenez, R. ; Morales-Muñoz, I. ; Gutierrez, M. ; Zabala, A. ; Sarró, S. ; Landin-Romero, R. ; Serna, De La ; Baeza, I. ; Parellada, M. ; Espliego, A. ; Juan, J.S. ; Aguilar, E.
Opposite cannabis-cognition associations in psychotic patients depending on family history
Financiación FP7 / Fp7 Funds
Resumen: The objective of this study is to investigate cognitive performance in a first-episode psychosis sample, when stratifying the interaction by cannabis use and familial or non-familial psychosis. Hierarchical-regression models were used to analyse this association in a sample of 268 first-episode psychosis patients and 237 controls. We found that cannabis use was associated with worse working memory, regardless of family history. However, cannabis use was clearly associated with worse cognitive performance in patients with no family history of psychosis, in cognitive domains including verbal memory, executive function and global cognitive index, whereas cannabis users with a family history of psychosis performed better in these domains. The main finding of the study is that there is an interaction between cannabis use and a family history of psychosis in the areas of verbal memory, executive function and global cognition: that is, cannabis use is associated with a better performance in patients with a family history of psychosis and a worse performance in those with no family history of psychosis. In order to confirm this hypothesis, future research should explore the actual expression of the endocannabinoid system in patients with and without a family history of psychosis.
Idioma: Inglés
DOI: 10.1371/journal.pone.0160949
Año: 2016
Publicado en: PloS one 11, 8 (2016), 0160949 [16pp]
ISSN: 1932-6203

Factor impacto JCR: 2.806 (2016)
Categ. JCR: MULTIDISCIPLINARY SCIENCES rank: 15 / 63 = 0.238 (2016) - Q1 - T1
Factor impacto SCIMAGO: 1.236 - Agricultural and Biological Sciences (miscellaneous) (Q1) - Medicine (miscellaneous) (Q1) - Biochemistry, Genetics and Molecular Biology (miscellaneous) (Q1)

Financiación: info:eu-repo/grantAgreement/EC/FP7/241909/EU/European Network of National Schizophrenia Networks Studying Gene-Environment Interactions/EU-GEI
Financiación: info:eu-repo/grantAgreement/EC/FP7/242114/EU/OPtimization of Treatment and Management of Schizophrenia in Europe (OPTiMiSE)/OPTIMISE
Financiación: info:eu-repo/grantAgreement/EC/FP7/602478/EU/Neuroimaging platform for characterisation of metabolic co-morbidities in psychotic disorders/METSY
Financiación: info:eu-repo/grantAgreement/EC/FP7/603196/EU/Translating neuroimaging findings from research into clinical practice/PSYSCAN
Financiación: info:eu-repo/grantAgreement/ES/ISCIII/PI-080208
Tipo y forma: Article (Published version)
Área (Departamento): Area Psiquiatría (Dpto. Medicina, Psiqu. y Derm.)

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 Record created 2016-11-30, last modified 2020-02-21


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