000057750 001__ 57750
000057750 005__ 20230421130003.0
000057750 0247_ $$2doi$$a10.1016/j.jtbi.2015.07.015
000057750 0248_ $$2sideral$$a91987
000057750 037__ $$aART-2015-91987
000057750 041__ $$aeng
000057750 100__ $$aEscribano, J.
000057750 245__ $$aModeling the formation of cell-matrix adhesions on a single 3D matrix fiber
000057750 260__ $$c2015
000057750 5060_ $$aAccess copy available to the general public$$fUnrestricted
000057750 5203_ $$aCell-matrix adhesions are crucial in different biological processes like tissue morphogenesis, cell motility, and extracellular matrix remodeling. These interactions that link cell cytoskeleton and matrix fibers are built through protein clutches, generally known as adhesion complexes. The adhesion formation process has been deeply studied in two-dimensional (2D) cases// however, the knowledge is limited for three-dimensional (3D) cases. In this work, we simulate different local extracellular matrix properties in order to unravel the fundamental mechanisms that regulate the formation of cell-matrix adhesions in 3D. We aim to study the mechanical interaction of these biological structures through a three dimensional discrete approach, reproducing the transmission pattern force between the cytoskeleton and a single extracellular matrix fiber. This numerical model provides a discrete analysis of the proteins involved including spatial distribution, interaction between them, and study of the different phenomena, such as protein clutches unbinding or protein unfolding.
000057750 536__ $$9info:eu-repo/grantAgreement/EUR/FP7/ERC2012-StG-306751$$9info:eu-repo/grantAgreement/ES/MINECO/DPI2012-38090-C03-01
000057750 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000057750 590__ $$a2.049$$b2015
000057750 591__ $$aMATHEMATICAL & COMPUTATIONAL BIOLOGY$$b14 / 56 = 0.25$$c2015$$dQ1$$eT1
000057750 591__ $$aBIOLOGY$$b25 / 86 = 0.291$$c2015$$dQ2$$eT1
000057750 592__ $$a1.072$$b2015
000057750 593__ $$aModeling and Simulation$$c2015$$dQ1
000057750 593__ $$aMedicine (miscellaneous)$$c2015$$dQ1
000057750 593__ $$aBiochemistry, Genetics and Molecular Biology (miscellaneous)$$c2015$$dQ1
000057750 593__ $$aAgricultural and Biological Sciences (miscellaneous)$$c2015$$dQ1
000057750 593__ $$aStatistics and Probability$$c2015$$dQ2
000057750 593__ $$aApplied Mathematics$$c2015$$dQ2
000057750 593__ $$aImmunology and Microbiology (miscellaneous)$$c2015$$dQ2
000057750 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/submittedVersion
000057750 700__ $$0(orcid)0000-0002-3514-6443$$aSánchez, M.T.
000057750 700__ $$0(orcid)0000-0002-9864-7683$$aGarcía-Aznar, J.M.$$uUniversidad de Zaragoza
000057750 7102_ $$15004$$2605$$aUniversidad de Zaragoza$$bDpto. Ingeniería Mecánica$$cÁrea Mec.Med.Cont. y Teor.Est.
000057750 773__ $$g384 (2015), 84-94$$pJ. theor. biol.$$tJournal of theoretical biology$$x0022-5193
000057750 8564_ $$s2695807$$uhttps://zaguan.unizar.es/record/57750/files/texto_completo.pdf$$yPreprint
000057750 8564_ $$s51648$$uhttps://zaguan.unizar.es/record/57750/files/texto_completo.jpg?subformat=icon$$xicon$$yPreprint
000057750 909CO $$ooai:zaguan.unizar.es:57750$$particulos$$pdriver
000057750 951__ $$a2023-04-21-12:38:12
000057750 980__ $$aARTICLE