57750 20230421130003.0 doi 10.1016/j.jtbi.2015.07.015 sideral 91987 ART-2015-91987 eng Escribano, J. Modeling the formation of cell-matrix adhesions on a single 3D matrix fiber 2015 Access copy available to the general public Unrestricted Cell-matrix adhesions are crucial in different biological processes like tissue morphogenesis, cell motility, and extracellular matrix remodeling. These interactions that link cell cytoskeleton and matrix fibers are built through protein clutches, generally known as adhesion complexes. The adhesion formation process has been deeply studied in two-dimensional (2D) cases// however, the knowledge is limited for three-dimensional (3D) cases. In this work, we simulate different local extracellular matrix properties in order to unravel the fundamental mechanisms that regulate the formation of cell-matrix adhesions in 3D. We aim to study the mechanical interaction of these biological structures through a three dimensional discrete approach, reproducing the transmission pattern force between the cytoskeleton and a single extracellular matrix fiber. This numerical model provides a discrete analysis of the proteins involved including spatial distribution, interaction between them, and study of the different phenomena, such as protein clutches unbinding or protein unfolding. info:eu-repo/grantAgreement/EUR/FP7/ERC2012-StG-306751 info:eu-repo/grantAgreement/ES/MINECO/DPI2012-38090-C03-01 info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 2.049 2015 MATHEMATICAL & COMPUTATIONAL BIOLOGY 14 / 56 = 0.25 2015 Q1 T1 BIOLOGY 25 / 86 = 0.291 2015 Q2 T1 1.072 2015 Modeling and Simulation 2015 Q1 Medicine (miscellaneous) 2015 Q1 Biochemistry, Genetics and Molecular Biology (miscellaneous) 2015 Q1 Agricultural and Biological Sciences (miscellaneous) 2015 Q1 Statistics and Probability 2015 Q2 Applied Mathematics 2015 Q2 Immunology and Microbiology (miscellaneous) 2015 Q2 info:eu-repo/semantics/article info:eu-repo/semantics/submittedVersion Sánchez, M.T. (orcid)0000-0002-3514-6443 García-Aznar, J.M. Universidad de Zaragoza (orcid)0000-0002-9864-7683 5004 605 Universidad de Zaragoza Dpto. Ingeniería Mecánica Área Mec.Med.Cont. y Teor.Est. 384 (2015), 84-94 J. theor. biol. Journal of theoretical biology 0022-5193 2695807 http://zaguan.unizar.es/record/57750/files/texto_completo.pdf Preprint 51648 http://zaguan.unizar.es/record/57750/files/texto_completo.jpg?subformat=icon icon Preprint oai:zaguan.unizar.es:57750 articulos driver 2023-04-21-12:38:12 ARTICLE