000057768 001__ 57768
000057768 005__ 20200221144336.0
000057768 0247_ $$2doi$$a10.1371/journal.pone.0165981
000057768 0248_ $$2sideral$$a97131
000057768 037__ $$aART-2016-97131
000057768 041__ $$aeng
000057768 100__ $$aWolters, M.
000057768 245__ $$aAssociations of whole blood n-3 and n-6 polyunsaturated fatty acids with blood pressure in children and adolescents -results from the IDEFICS/I.Family cohort
000057768 260__ $$c2016
000057768 5060_ $$aAccess copy available to the general public$$fUnrestricted
000057768 5203_ $$aBackground Polyunsaturated n-3 and n-6 polyunsaturated fatty acids (PUFA) are precursors of biologically active metabolites that affect blood pressure (BP) regulation. This study investigated the association of n-3 and n-6 PUFA and BP in children and adolescents. Methods In a subsample of 1267 children aged 2-9 years at baseline of the European IDEFICS (Identification and prevention of dietary- and lifestyle-induced health effects in children and infants) cohort whole blood fatty acids were measured by a validated gas chromatographic method. Systolic and diastolic BP was measured at baseline and after two and six years. Mixed-effects models were used to assess the associations between fatty acids at baseline and BP z-scores over time adjusting for relevant covariables. Models were further estimated stratified by sex and weight status. Results The baseline level of arachidonic acid was positively associated with subsequent systolic BP (ß = 0.08, P = 0.002) and diastolic BP (ß = 0.07, P<0.001). In thin/normal weight children, baseline alpha-linolenic (ß = -1.13, P = 0.003) and eicosapentaenoic acid (ß = -0.85, P = 0.003) levels were inversely related to baseline and also to subsequent systolic BP and alpha-linolenic acid to subsequent diastolic BP. In overweight/obese children, baseline eicosapentaenoic acid level was positively associated with baseline diastolic BP (ß = 0.54, P = 0.005). Conclusions Low blood arachidonic acid levels in the whole sample and high n-3 PUFA levels in thin/normal weight children are associated with lower and therefore healthier BP. The beneficial effects of high n-3 PUFA on BP were not observed in overweight/obese children, suggesting that they may have been overlaid by the unfavorable effects of excess weight.
000057768 536__ $$9info:eu-repo/grantAgreement/EC/FP7/266044/EU/Determinants of eating behaviour in European children, adolescents and their parents/I.FAMILY$$9info:eu-repo/grantAgreement/EUR/FP6/FOOD-016181
000057768 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000057768 590__ $$a2.806$$b2016
000057768 591__ $$aMULTIDISCIPLINARY SCIENCES$$b15 / 63 = 0.238$$c2016$$dQ1$$eT1
000057768 592__ $$a1.236$$b2016
000057768 593__ $$aAgricultural and Biological Sciences (miscellaneous)$$c2016$$dQ1
000057768 593__ $$aMedicine (miscellaneous)$$c2016$$dQ1
000057768 593__ $$aBiochemistry, Genetics and Molecular Biology (miscellaneous)$$c2016$$dQ1
000057768 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000057768 700__ $$aPala, V.
000057768 700__ $$aRusso, P.
000057768 700__ $$aRisé, P.
000057768 700__ $$0(orcid)0000-0003-0454-653X$$aMoreno, L.A.$$uUniversidad de Zaragoza
000057768 700__ $$aDe Henauw, S.
000057768 700__ $$aMehlig, K.
000057768 700__ $$aVeidebaum, T.
000057768 700__ $$aMolnár, D.
000057768 700__ $$aTornaritis, M.
000057768 700__ $$aGalli, C.
000057768 700__ $$aAhrens, W.
000057768 700__ $$aBörnhorst, C.
000057768 7102_ $$11006$$2255$$aUniversidad de Zaragoza$$bDpto. Fisiatría y Enfermería$$cÁrea Enfermería
000057768 773__ $$g11, 11 (2016), 0165981[17 pp]$$pPLoS One$$tPloS one$$x1932-6203
000057768 8564_ $$s1501704$$uhttps://zaguan.unizar.es/record/57768/files/texto_completo.pdf$$yVersión publicada
000057768 8564_ $$s99150$$uhttps://zaguan.unizar.es/record/57768/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000057768 909CO $$ooai:zaguan.unizar.es:57768$$particulos$$pdriver
000057768 951__ $$a2020-02-21-13:47:49
000057768 980__ $$aARTICLE