000057778 001__ 57778 000057778 005__ 20200221144223.0 000057778 0247_ $$2doi$$a10.3389/fneur.2016.00182 000057778 0248_ $$2sideral$$a97027 000057778 037__ $$aART-2016-97027 000057778 041__ $$aeng 000057778 100__ $$aFrejo, L. 000057778 245__ $$aClinical subgroups in bilateral meniere disease 000057778 260__ $$c2016 000057778 5060_ $$aAccess copy available to the general public$$fUnrestricted 000057778 5203_ $$aMeniere disease (MD) is a heterogeneous clinical condition characterized by sensorineural hearing loss, episodic vestibular symptoms, and tinnitus associated with several comorbidities, such as migraine or autoimmune disorders (AD). The frequency of bilateral involvement may range from 5 to 50%, and it depends on the duration of the disease. We have performed a two-step cluster analysis in 398 patients with bilateral MD (BMD) to identify the best predictors to define clinical subgroups with a potential different etiology to improve the phenotyping of BMD and to develop new treatments. We have defined five clinical variants in BMD. Group 1 is the most frequently found, includes 46% of patients, and is defined by metachronic hearing loss without migraine and without AD. Group 2 is found in 17% of patients, and it is defined by synchronic hearing loss without migraine or AD. Group 3, with 13% of patients, is characterized by familial MD, while group 4, that includes 12% of patients, is associated by the presence of migraine in all cases. Group 5 is found in 11% of patients and is defined by AD. This approach can be helpful in selecting patients for genetic and clinical research. However, further studies will be required to improve the phenotyping in these clinical variants for a better understanding of the diverse etiological factors contributing to BMD. 000057778 536__ $$9info:eu-repo/grantAgreement/ES/FIS/PI13/01242 000057778 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/ 000057778 590__ $$a3.552$$b2016 000057778 591__ $$aNEUROSCIENCES$$b84 / 258 = 0.326$$c2016$$dQ2$$eT1 000057778 591__ $$aCLINICAL NEUROLOGY$$b50 / 194 = 0.258$$c2016$$dQ2$$eT1 000057778 592__ $$a1.56$$b2016 000057778 593__ $$aNeurology (clinical)$$c2016$$dQ1 000057778 593__ $$aNeurology$$c2016$$dQ2 000057778 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion 000057778 700__ $$aSoto-Varela, A. 000057778 700__ $$aSantos-Perez, S. 000057778 700__ $$aAran, I. 000057778 700__ $$aBatuecas-Caletrio, A. 000057778 700__ $$aPerez-Guillen, V. 000057778 700__ $$aPerez-Garrigues, H. 000057778 700__ $$0(orcid)0000-0002-6561-3305$$aFraile, J.$$uUniversidad de Zaragoza 000057778 700__ $$aMartin-Sanz, E. 000057778 700__ $$aTapia, M.C. 000057778 700__ $$aTrinidad, G. 000057778 700__ $$aGarcía-Arumi, A.M. 000057778 700__ $$aGonzález-Aguado, R. 000057778 700__ $$aEspinosa-Sanchez, J. 000057778 700__ $$aMarques, P. 000057778 700__ $$aPerez, P. 000057778 700__ $$aBenitez, J. 000057778 700__ $$aLopez-Escamez, J. 000057778 700__ $$aAmor-Dorado, J. 000057778 700__ $$aHuarte, R.M. 000057778 700__ $$aPerez-Fernandez, N. 000057778 700__ $$aSanz, R. 000057778 700__ $$aDominguez, M.O. 000057778 700__ $$aTeggi, R. 000057778 7102_ $$11004$$2653$$aUniversidad de Zaragoza$$bDpto. Cirugía,Ginecol.Obstetr.$$cÁrea Otorrinolaringología 000057778 773__ $$g7 (2016), 182 [10 pp]$$pFront. neurol.$$tFrontiers in Neurology$$x1664-2295 000057778 8564_ $$s910411$$uhttps://zaguan.unizar.es/record/57778/files/texto_completo.pdf$$yVersión publicada 000057778 8564_ $$s98233$$uhttps://zaguan.unizar.es/record/57778/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada 000057778 909CO $$ooai:zaguan.unizar.es:57778$$particulos$$pdriver 000057778 951__ $$a2020-02-21-13:16:19 000057778 980__ $$aARTICLE