Cut-offs and response criteria for the Hospital Universitario la Princesa Index (HUPI) and their comparison to widely-used indices of disease activity in rheumatoid arthritis

González-Álvaro, I.; Corteguera Coro, M.; Ramos López, P.; Peiró Callizo, E.; Mazzucheli, R.; Gratacos Masmitja, J.; Gómez Centeno, E.; Manero Ruiz, F.J.; Rodríguez Gómez, M.; Fiter Aresté, J.; Castañeda, S.; Zarco Montejo, P.; Tena Marsá, X.; Aragón Díez, A.; Mateo Bernardo, I.; Cebrian Mendez, L.; González Hernández, T.; Beltrán Fabregat, J.; Cuadra Díaz, J.L.; Tenorio Martín, M.; Santos, Rey Rey; Casado, E.; Medrano, San Idelfonso; Abasolo Alcazar, L.; Loza Santamaria, E.; Cuesta, E.; Torres Martín, Mc; Beltrán Audera, J.; Andreu Sánchez, J.L.; García-Vadillo, A.; Toledano, E.; Batlle Gualda, E.; Jiménez Palop, M.; Miguel, Alegre De; Carmona Ortells, L.; Valls, M.; Giménez Ubeda, E.; Sampedro Alvarez, J.; Galindo Izquierdo, M.; Quirós Donate, J.; Pecondón Español, A.; Belmonte Serrano, M.A.; Zubieta Tabernero, J.; Naranjo Hernández, A.; García Meijide, J.A.; Juan Mas, A.; Balsa Criado, A.; Gómez Vaquero, C.; Instxaurbe, A.R.; Castrejón, I.; Freire Gonzalez, M.; García Gómez, M.C.; Bonilla Hernan, G.; Villaverde García, V.; Diego, Valdazo De; Grandal Delgado, Y.; Carmona, L.; Hernández, Del R.; González Gómez, M.L.; Mayordomo González, L.; Roselló Pardo, R.; López Longo, F.J.; Maese Manzano, J.; Júdez Navarro, E.; González Fernández, M.J.; González-Alvaro, I.; Ortiz, A.M.; Rodríguez López, M.; Irigoyen Oyarzabal, M.V.; Sanmartí Sala, R.; Caro Fernández, N.; Ureña Garnica, I.; González-Montagut Gómez, C.; Rivera Redondo, J.; Larrosa Padro, M.

doi:10.1371/journal.pone.0161727

000057781 001__ 57781
000057781 005__ 20200221144224.0
000057781 0247_ $$2doi$$a10.1371/journal.pone.0161727
000057781 0248_ $$2sideral$$a97040
000057781 037__ $$aART-2016-97040
000057781 041__ $$aeng
000057781 100__ $$aGonzález-Álvaro, I.
000057781 245__ $$aCut-offs and response criteria for the Hospital Universitario la Princesa Index (HUPI) and their comparison to widely-used indices of disease activity in rheumatoid arthritis
000057781 260__ $$c2016
000057781 5060_ $$aAccess copy available to the general public$$fUnrestricted
000057781 5203_ $$aObjective To estimate cut-off points and to establish response criteria for the Hospital Universitario La Princesa Index (HUPI) in patients with chronic polyarthritis. Methods Two cohorts, one of early arthritis (Princesa Early Arthritis Register Longitudinal PEARL] study) and other of long-term rheumatoid arthritis (Estudio de la Morbilidad y Expresión Clínica de la Artritis Reumatoide EMECAR]) including altogether 1200 patients were used to determine cut-off values for remission, and for low, moderate and high activity through receiver operating curve (ROC) analysis. The areas under ROC (AUC) were compared to those of validated indexes (SDAI, CDAI, DAS28). ROC analysis was also applied to establish minimal and relevant clinical improvement for HUPI. Results The best cut-off points for HUPI are 2, 5 and 9, classifying RA activity as remission if =2, low disease activity if >2 and =5), moderate if >5 and <9 and high if =9. HUPI''s AUC to discriminate between low-moderate activity was 0.909 and between moderate-high activity 0.887. DAS28''s AUCs were 0.887 and 0.846, respectively; both indices had higher accuracy than SDAI (AUCs: 0.832 and 0.756) and CDAI (AUCs: 0.789 and 0.728). HUPI discriminates remission better than DAS28-ESR in early arthritis, but similarly to SDAI. The HUPI cut-off for minimal clinical improvement was established at 2 and for relevant clinical improvement at 4. Response criteria were established based on these cut-off values. Conclusions The cut-offs proposed for HUPI perform adequately in patients with either early or long term arthritis.
000057781 536__ $$9info:eu-repo/grantAgreement/ES/MINECO/ISCIII-PI14-00442$$9info:eu-repo/grantAgreement/ES/MINECO/ISCIII-RD12-0009-0017
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000057781 591__ $$aMULTIDISCIPLINARY SCIENCES$$b15 / 63 = 0.238$$c2016$$dQ1$$eT1
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000057781 593__ $$aAgricultural and Biological Sciences (miscellaneous)$$c2016$$dQ1
000057781 593__ $$aMedicine (miscellaneous)$$c2016$$dQ1
000057781 593__ $$aBiochemistry, Genetics and Molecular Biology (miscellaneous)$$c2016$$dQ1
000057781 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000057781 700__ $$aCastrejón, I.
000057781 700__ $$aOrtiz, A.M.
000057781 700__ $$aToledano, E.
000057781 700__ $$aCastañeda, S.
000057781 700__ $$aGarcía-Vadillo, A.
000057781 700__ $$aCarmona, L.
000057781 700__ $$aAbasolo Alcazar, L.
000057781 700__ $$aMiguel, Alegre De
000057781 700__ $$aAndreu Sánchez, J.L.
000057781 700__ $$aAragón Díez, A.
000057781 700__ $$aBalsa Criado, A.
000057781 700__ $$aBatlle Gualda, E.
000057781 700__ $$aBelmonte Serrano, M.A.
000057781 700__ $$aBeltrán Audera, J.
000057781 700__ $$aBeltrán Fabregat, J.
000057781 700__ $$aBonilla Hernan, G.
000057781 700__ $$aCarmona Ortells, L.
000057781 700__ $$aCaro Fernández, N.
000057781 700__ $$aCasado, E.
000057781 700__ $$aCebrian Mendez, L.
000057781 700__ $$aCorteguera Coro, M.
000057781 700__ $$aCuadra Díaz, J.L.
000057781 700__ $$aCuesta, E.
000057781 700__ $$aFiter Aresté, J.
000057781 700__ $$aFreire Gonzalez, M.
000057781 700__ $$aGalindo Izquierdo, M.
000057781 700__ $$aGarcía Meijide, J.A.
000057781 700__ $$aGarcía Gómez, M.C.
000057781 700__ $$aGiménez Ubeda, E.
000057781 700__ $$aGómez Centeno, E.
000057781 700__ $$aGómez Vaquero, C.
000057781 700__ $$aGonzález Fernández, M.J.
000057781 700__ $$aGonzález Gómez, M.L.
000057781 700__ $$aGonzález Hernández, T.
000057781 700__ $$aGonzález-Alvaro, I.
000057781 700__ $$aGonzález-Montagut Gómez, C.
000057781 700__ $$aGrandal Delgado, Y.
000057781 700__ $$aGratacos Masmitja, J.
000057781 700__ $$aHernández, Del R.
000057781 700__ $$aInstxaurbe, A.R.
000057781 700__ $$aIrigoyen Oyarzabal, M.V.
000057781 700__ $$aJiménez Palop, M.
000057781 700__ $$aJuan Mas, A.
000057781 700__ $$aJúdez Navarro, E.
000057781 700__ $$aLarrosa Padro, M.
000057781 700__ $$aLópez Longo, F.J.
000057781 700__ $$aLoza Santamaria, E.
000057781 700__ $$aMaese Manzano, J.
000057781 700__ $$aManero Ruiz, F.J.
000057781 700__ $$aMateo Bernardo, I.
000057781 700__ $$aMayordomo González, L.
000057781 700__ $$aMazzucheli, R.
000057781 700__ $$0(orcid)0000-0001-9303-4995$$aMedrano, San Idelfonso$$uUniversidad de Zaragoza
000057781 700__ $$aNaranjo Hernández, A.
000057781 700__ $$0(orcid)0000-0002-8458-081X$$aPecondón Español, A.$$uUniversidad de Zaragoza
000057781 700__ $$aPeiró Callizo, E.
000057781 700__ $$aQuirós Donate, J.
000057781 700__ $$aRamos López, P.
000057781 700__ $$aRivera Redondo, J.
000057781 700__ $$aRodríguez Gómez, M.
000057781 700__ $$aRodríguez López, M.
000057781 700__ $$aRoselló Pardo, R.
000057781 700__ $$aSampedro Alvarez, J.
000057781 700__ $$aSanmartí Sala, R.
000057781 700__ $$aSantos, Rey Rey
000057781 700__ $$aTena Marsá, X.
000057781 700__ $$aTenorio Martín, M.
000057781 700__ $$aTorres Martín, Mc
000057781 700__ $$aUreña Garnica, I.
000057781 700__ $$aDiego, Valdazo De
000057781 700__ $$aValls, M.
000057781 700__ $$aVillaverde García, V.
000057781 700__ $$aZarco Montejo, P.
000057781 700__ $$aZubieta Tabernero, J.
000057781 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina
000057781 773__ $$g11, 9 (2016),   0161727[]$$pPLoS One$$tPloS one$$x1932-6203
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000057781 951__ $$a2020-02-21-13:16:56
000057781 980__ $$aARTICLE

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