000057782 001__ 57782
000057782 005__ 20241108104650.0
000057782 0247_ $$2doi$$a10.1186/s12711-016-0258-1
000057782 0248_ $$2sideral$$a97041
000057782 037__ $$aART-2016-97041
000057782 041__ $$aeng
000057782 100__ $$0(orcid)0000-0001-9869-524X$$aGonzález-Rodríguez, A.
000057782 245__ $$aOn the performance of tests for the detection of signatures of selection: a case study with the Spanish autochthonous beef cattle populations
000057782 260__ $$c2016
000057782 5060_ $$aAccess copy available to the general public$$fUnrestricted
000057782 5203_ $$aBackground: Procedures for the detection of signatures of selection can be classified according to the source of information they use to reject the null hypothesis of absence of selection. Three main groups of tests can be identified that are based on: (1) the analysis of the site frequency spectrum, (2) the study of the extension of the linkage disequilibrium across the length of the haplotypes that surround the polymorphism, and (3) the differentiation among populations. The aim of this study was to compare the performance of a subset of these procedures by using a dataset on seven Spanish autochthonous beef cattle populations. Results: Analysis of the correlations between the logarithms of the statistics that were obtained by 11 tests for detecting signatures of selection at each single nucleotide polymorphism confirmed that they can be clustered into the three main groups mentioned above. A factor analysis summarized the results of the 11 tests into three canonical axes that were each associated with one of the three groups. Moreover, the signatures of selection identified with the first and second groups of tests were shared across populations, whereas those with the third group were more breed-specific. Nevertheless, an enrichment analysis identified the metabolic pathways that were associated with each group; they coincided with canonical axes and were related to immune response, muscle development, protein biosynthesis, skin and pigmentation, glucose metabolism, fat metabolism, embryogenesis and morphology, heart and uterine metabolism, regulation of the hypothalamic-pituitary-thyroid axis, hormonal, cellular cycle, cell signaling and extracellular receptors. Conclusions: We show that the results of the procedures used to identify signals of selection differed substantially between the three groups of tests. However, they can be classified using a factor analysis. Moreover, each canonical factor that coincided with a group of tests identified different signals of selection, which could be attributed to processes of selection that occurred at different evolutionary times. Nevertheless, the metabolic pathways that were associated with each group of tests were similar, which suggests that the selection events that occurred during the evolutionary history of the populations probably affected the same group of traits.
000057782 536__ $$9info:eu-repo/grantAgreement/ES/MINECO/BES-2011-045434$$9info:eu-repo/grantAgreement/ES/MINECO/AGL2010-15903$$9info:eu-repo/grantAgreement/EC/FP7/289592/EU/Next generation European system for cattle improvement and management/GENE2FARM$$9info:eu-repo/grantAgreement/ES/DGA/A51
000057782 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000057782 590__ $$a2.964$$b2016
000057782 591__ $$aAGRICULTURE, DAIRY & ANIMAL SCIENCE$$b2 / 56 = 0.036$$c2016$$dQ1$$eT1
000057782 591__ $$aGENETICS & HEREDITY$$b70 / 165 = 0.424$$c2016$$dQ2$$eT2
000057782 592__ $$a1.534$$b2016
000057782 593__ $$aAnimal Science and Zoology$$c2016$$dQ1
000057782 593__ $$aMedicine (miscellaneous)$$c2016$$dQ1
000057782 593__ $$aEcology, Evolution, Behavior and Systematics$$c2016$$dQ1
000057782 593__ $$aGenetics$$c2016$$dQ2
000057782 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000057782 700__ $$aMunilla, S.
000057782 700__ $$0(orcid)0000-0002-1335-7610$$aMouresan, E.F.
000057782 700__ $$aCañas-Álvarez, J.J.
000057782 700__ $$aDíaz, C.
000057782 700__ $$aPiedrafita, J.
000057782 700__ $$0(orcid)0000-0002-3042-2250$$aAltarriba, J.$$uUniversidad de Zaragoza
000057782 700__ $$aBaro, J.Á.
000057782 700__ $$aMolina, A.
000057782 700__ $$0(orcid)0000-0001-6256-5478$$aVarona, L.$$uUniversidad de Zaragoza
000057782 7102_ $$11001$$2420$$aUniversidad de Zaragoza$$bDpto. Anatom.,Embri.Genét.Ani.$$cÁrea Genética
000057782 773__ $$g48, 1 (2016), 1-12$$pGenet. sel. evol.$$tGenetics Selection Evolution$$x0999-193X
000057782 8564_ $$s2628152$$uhttps://zaguan.unizar.es/record/57782/files/texto_completo.pdf$$yVersión publicada
000057782 8564_ $$s87759$$uhttps://zaguan.unizar.es/record/57782/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000057782 909CO $$ooai:zaguan.unizar.es:57782$$particulos$$pdriver
000057782 951__ $$a2024-11-08-10:44:42
000057782 980__ $$aARTICLE