000057788 001__ 57788
000057788 005__ 20200221144318.0
000057788 0247_ $$2doi$$a10.1371/journal.pone.0165711
000057788 0248_ $$2sideral$$a97066
000057788 037__ $$aART-2016-97066
000057788 041__ $$aeng
000057788 100__ $$aMinchole, E.
000057788 245__ $$aSeasonal influenza A H1N1pdm09 virus and severe outcomes: A reason for broader vaccination in non-elderly, at-risk people
000057788 260__ $$c2016
000057788 5060_ $$aAccess copy available to the general public$$fUnrestricted
000057788 5203_ $$aBackground: Recent pandemics of influenza A H1N1pdm09 virus have caused severe illness, especially in young people. Very few studies on influenza A H1N1pdm09 in post-pandemic periods exist, and there is no information on the severity of both seasonal influenza A(H1N1) and A (H3N2) from the same season, adjusting for potential confounders, including vaccine. Methods and Results: We performed a retrospective observational study of adults hospitalized during the 2014 season with influenza A(H1N1) or A(H3N2). All patients underwent the same diagnostic and therapeutic protocol in a single hospital, including early Oseltamivir therapy. We included 234 patients: 146 (62.4%) influenza A(H1N1) and 88 (37.6%) A(H3N2). A(H1N1) patients were younger (p<0.01), developed more pneumonia (p<0.01), respiratory complications (p = 0.015), ARDS (p = 0.047), and septic shock (p = 0.049), were more frequently admitted to the ICU (p = 0.022), required IMV (p = 0.049), and were less frequently vaccinated (p = 0.008). After adjusting for age, comorbidities, time from onset of illness, and vaccine status, influenza A(H1N1) (OR, 2.525), coinfection (OR, 2.821), and no vaccination (OR, 3.086) were independent risk factors for severe disease. Conclusions: Hospitalized patients with influenza A(H1N1) were more than twice as likely to have severe influenza. They were younger and most had not received the vaccine. Our findings suggest that seasonal influenza A(H1N1) maintains some features of pandemic viruses, and recommend wider use of vaccination in younger adult high-risk patients.
000057788 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000057788 590__ $$a2.806$$b2016
000057788 591__ $$aMULTIDISCIPLINARY SCIENCES$$b15 / 63 = 0.238$$c2016$$dQ1$$eT1
000057788 592__ $$a1.236$$b2016
000057788 593__ $$aAgricultural and Biological Sciences (miscellaneous)$$c2016$$dQ1
000057788 593__ $$aMedicine (miscellaneous)$$c2016$$dQ1
000057788 593__ $$aBiochemistry, Genetics and Molecular Biology (miscellaneous)$$c2016$$dQ1
000057788 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000057788 700__ $$aFigueredo, A.L.
000057788 700__ $$aOmeñaca, M.
000057788 700__ $$aPanadero, C.
000057788 700__ $$aRoyo, L.
000057788 700__ $$aVengoechea, J.J.
000057788 700__ $$aFandos, S.
000057788 700__ $$aDe Pablo, F.
000057788 700__ $$0(orcid)0000-0003-3670-2664$$aBello, S.$$uUniversidad de Zaragoza
000057788 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina
000057788 773__ $$g11, 11 (2016), 0165711[15pp]$$pPLoS One$$tPloS one$$x1932-6203
000057788 8564_ $$s1415539$$uhttps://zaguan.unizar.es/record/57788/files/texto_completo.pdf$$yVersión publicada
000057788 8564_ $$s90964$$uhttps://zaguan.unizar.es/record/57788/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000057788 909CO $$ooai:zaguan.unizar.es:57788$$particulos$$pdriver
000057788 951__ $$a2020-02-21-13:40:14
000057788 980__ $$aARTICLE