Magnetic Nanoparticles as Intraocular Drug Delivery System to Target Retinal Pigmented Epithelium (RPE)
Resumen: One of the most challenging efforts in drug delivery is the targeting of the eye. The eye structure and barriers render this organ poorly permeable to drugs. Quite recently the entrance of nanoscience in ocular drug delivery has improved the penetration and half-life of drugs, especially in the anterior eye chamber, while targeting the posterior chamber is still an open issue. The retina and the retinal pigment epithelium/choroid tissues, located in the posterior eye chamber, are responsible for the majority of blindness both in childhood and adulthood. In the present study, we used magnetic nanoparticles (MNPs) as a nanotool for ocular drug delivery that is capable of specific localization in the retinal pigmented epithelium (RPE) layer. We demonstrate that, following intraocular injection in Xenopus embryos, MNPs localize specifically in RPE where they are retained for several days. The specificity of the localization did not depend on particle size and surface properties of the MNPs used in this work. Moreover, through similar experiments in zebrafish, we demonstrated that the targeting of RPE by the nanoparticles is not specific for the Xenopus species.
Idioma: Inglés
DOI: 10.3390/ijms15011590
Año: 2014
ISSN: 1661-6596

Factor impacto JCR: 2.862 (2014)
Categ. JCR: CHEMISTRY, MULTIDISCIPLINARY rank: 45 / 154 = 0.292 (2014) - Q2 - T1
Categ. JCR: BIOCHEMISTRY & MOLECULAR BIOLOGY rank: 134 / 289 = 0.464 (2014) - Q2 - T2

Factor impacto SCIMAGO:

Financiación: info:eu-repo/grantAgreement/ES/MINECO/MAT2010-19326
Tipo y forma: Article (Published version)
Área (Departamento): Física de la Materia Condensada (Departamento de Física de la Materia Condensada)

Creative Commons You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.

Exportado de SIDERAL (2016-12-13-12:55:03)

Este artículo se encuentra en las siguientes colecciones:
Articles > Artículos por área > Física de la Materia Condensada

 Record created 2016-12-13, last modified 2017-03-27

Versión publicada:
Rate this document:

Rate this document:
(Not yet reviewed)