000057814 001__ 57814
000057814 005__ 20170504090233.0
000057814 0247_ $$2doi$$a10.3390/ijms151223501
000057814 0248_ $$2sideral$$a88988
000057814 037__ $$aART-2014-88988
000057814 041__ $$aeng
000057814 100__ $$aHorna-Terrón, E.
000057814 245__ $$aTXNDC5, a newly discovered disulfide isomerase with a key role in cell physiology and pathology
000057814 260__ $$c2014
000057814 5060_ $$aAccess copy available to the general public$$fUnrestricted
000057814 5203_ $$aThioredoxin domain-containing 5 (TXNDC5) is a member of the protein disulfide isomerase family, acting as a chaperone of endoplasmic reticulum under not fully characterized conditions As a result, TXNDC5 interacts with many cell proteins, contributing to their proper folding and correct formation of disulfide bonds through its thioredoxin domains. Moreover, it can also work as an electron transfer reaction, recovering the functional isoform of other protein disulfide isomerases, replacing reduced glutathione in its role. Finally, it also acts as a cellular adapter, interacting with the N-terminal domain of adiponectin receptor. As can be inferred from all these functions, TXNDC5 plays an important role in cell physiology; therefore, dysregulation of its expression is associated with oxidative stress, cell ageing and a large range of pathologies such as arthritis, cancer, diabetes, neurodegenerative diseases, vitiligo and virus infections. Its implication in all these important diseases has made TXNDC5 a susceptible biomarker or even a potential pharmacological target.
000057814 536__ $$9info:eu-repo/grantAgreement/ES/MICINN/SAF010-14958$$9info:eu-repo/grantAgreement/ES/DGA/B69$$9info:eu-repo/grantAgreement/ES/CICYT-FEDER/2013-41651-R
000057814 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000057814 590__ $$a2.862$$b2014
000057814 591__ $$aCHEMISTRY, MULTIDISCIPLINARY$$b45 / 154 = 0.292$$c2014$$dQ2$$eT1
000057814 591__ $$aBIOCHEMISTRY & MOLECULAR BIOLOGY$$b134 / 290 = 0.462$$c2014$$dQ2$$eT2
000057814 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000057814 700__ $$aPradilla-Dieste, A.
000057814 700__ $$aSánchez-de-Diego, C.
000057814 700__ $$0(orcid)0000-0002-8251-8457$$aOsada, J.$$uUniversidad de Zaragoza
000057814 7102_ $$11002$$2060$$aUniversidad de Zaragoza$$bDepartamento de Bioquímica y Biología Molecular y Celular$$cBioquímica y Biología Molecular
000057814 773__ $$g15, 12 (2014), 23501-23518$$pInt. j. mol. sci.$$tINTERNATIONAL JOURNAL OF MOLECULAR SCIENCES$$x1661-6596
000057814 8564_ $$s1503903$$uhttps://zaguan.unizar.es/record/57814/files/texto_completo.pdf$$yVersión publicada
000057814 8564_ $$s85134$$uhttps://zaguan.unizar.es/record/57814/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000057814 909CO $$ooai:zaguan.unizar.es:57814$$particulos$$pdriver
000057814 951__ $$a2017-05-04-09:00:06
000057814 980__ $$aARTICLE