doi:10.1038/bjc.2014.38engBujanda, L.Sarasqueta, C.Lanas, Á.Quintero, E.Cubiella, J.Hernandez, V.Morillas, J.D.Perez-Fernández, T.Salas, D.Andreu, M.Carballo, F.Bessa, X.Portillo, I.Jover, R.Balaguer, F.Cosme, A.Castells, A.Effect of oral anticoagulants on the outcome of faecal immunochemical testART-2014-86486Background: We aimed to evaluate whether oral anticoagulants (OACs) alter faecal immunochemical test (FIT) performance in average-risk colorectal cancer (CRC) screening. Methods: Individuals aged 50–69 years were invited to receive one FIT sample (cutoff 75¿ng¿ml–1) between November 2008 and June 2011. Results: Faecal immunochemical test was positive in 9.3% (21 out of 224) of users of OAC and 6.2% (365 out of 5821) of non-users (P-trend=0.07). The positive predictive value (PPV) for advanced neoplasia (AN) in non-users was 50.4% vs 47.6% in users (odds ratio, 0.70; 95% CI, 0.3–1.8; P=0.5). The PPV for AN in OAC more antiplatelets (aspirin or clopidogrel) was 75% (odds ratio, 2; 95% CI, 0.4–10.8; P=0.4). Conclusions: Oral anticoagulant did not significantly modify the PPV for AN in this population-based colorectal screening program. The detection rate of advanced adenoma was higher in the combination OAC more antiplatelets.2014http://zaguan.unizar.es/record/5783810.1038/bjc.2014.38http://zaguan.unizar.es/record/57838oai:zaguan.unizar.es:57838info:eu-repo/grantAgreement/ES/ISCIII/PI08-90717BRITISH JOURNAL OF CANCER 110, 5 (2014), 1334-1337by-nc-sahttp://creativecommons.org/licenses/by-nc-sa/3.0/es/info:eu-repo/semantics/openAccess