000057874 001__ 57874
000057874 005__ 20200221144342.0
000057874 0247_ $$2doi$$a10.1136/lupus-2016-000153
000057874 0248_ $$2sideral$$a96100
000057874 037__ $$aART-2016-96100
000057874 041__ $$aeng
000057874 100__ $$aRuiz-Irastorza, G.
000057874 245__ $$aFirst month prednisone dose predicts prednisone burden during the following 11 months: An observational study from the RELES cohort
000057874 260__ $$c2016
000057874 5060_ $$aAccess copy available to the general public$$fUnrestricted
000057874 5203_ $$aAim: To study the influence of prednisone dose during the first month after systemic lupus erythematosus (SLE) diagnosis (prednisone-1) on glucocorticoid burden during the subsequent 11 months (prednisone-2–12). Methods: 223 patients from the Registro Español de Lupus Eritematoso Sistémico inception cohort were studied. The cumulative dose of prednisone-1 and prednisone-2–12 were calculated and recoded into a four-level categorical variable: no prednisone, low dose (up to 7.5 mg/day), medium dose (up to 30 mg/day) and high dose (over 30 mg/day). The association between the cumulative prednisone-1 and prednisone-2–12 doses was tested. We analysed whether the four-level prednisone-1 categorical variable was an independent predictor of an average dose >7.5 mg/day of prednisone-2–12. Adjusting variables included age, immunosuppressives, antimalarials, methyl-prednisolone pulses, lupus nephritis and baseline SLE Disease Activity Index (SLEDAI). Results: Within the first month, 113 patients (51%) did not receive any prednisone, 24 patients (11%) received average low doses, 46 patients (21%) received medium doses and 40 patients (18%) received high doses. There was a strong association between prednisone-1 and prednisone-2–12 dose categories (p<0.001). The cumulative prednisone-1 dose was directly associated with the cumulative prednisone-2–12 dose (p<0.001). Compared with patients on no prednisone, patients taking medium (adjusted OR 5.27, 95% CI 2.18 to 12.73) or high-dose prednisone-1 (adjusted OR 10.5, 95% CI 3.8 to 29.17) were more likely to receive prednisone-2–12 doses of >7.5 mg/day, while patients receiving low-dose prednisone-1 were not (adjusted OR 1.4, 95% CI 0. 0.38 to 5.2). If the analysis was restricted to the 158 patients with a baseline SLEDAI of =6, the model did not change. Conclusion: The dose of prednisone during the first month after the diagnosis of SLE is an independent predictor of prednisone burden during the following 11 months.
000057874 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc$$uhttp://creativecommons.org/licenses/by-nc/3.0/es/
000057874 592__ $$a1.248$$b2016
000057874 593__ $$aMedicine (miscellaneous)$$c2016$$dQ1
000057874 593__ $$aImmunology$$c2016$$dQ2
000057874 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000057874 700__ $$aGarcia, M.
000057874 700__ $$aEspinosa, G.
000057874 700__ $$aCaminal, L.
000057874 700__ $$aMitjavila, F.
000057874 700__ $$aGonzález-León, R.
000057874 700__ $$aSopenã, B.
000057874 700__ $$aCanora, J.
000057874 700__ $$aVillalba, M.V.
000057874 700__ $$aRodríguez-Carballeira, M.
000057874 700__ $$aLópez-Dupla, J.M.
000057874 700__ $$aCallejas, J.L.
000057874 700__ $$aCastro, A.
000057874 700__ $$aTolosa, C.
000057874 700__ $$aSánchez-Garciá, M.E.
000057874 700__ $$0(orcid)0000-0001-7563-7880$$aPérez-Conesa, M.$$uUniversidad de Zaragoza
000057874 700__ $$aNavarrete-Navarrete, N.
000057874 700__ $$aRodríguez, A.P.
000057874 700__ $$aHerranz, M.T.
000057874 700__ $$aPallarés, L.
000057874 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina
000057874 773__ $$g3, 1 (2016), e000153 [6 pp]$$pLupus sci. med.$$tLupus Science and Medicine$$x2053-8790
000057874 8564_ $$s528523$$uhttps://zaguan.unizar.es/record/57874/files/texto_completo.pdf$$yVersión publicada
000057874 8564_ $$s39683$$uhttps://zaguan.unizar.es/record/57874/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000057874 909CO $$ooai:zaguan.unizar.es:57874$$particulos$$pdriver
000057874 951__ $$a2020-02-21-13:51:04
000057874 980__ $$aARTICLE