000057913 001__ 57913
000057913 005__ 20161217123922.0
000057913 0247_ $$2doi$$a10.1155/2014/925101
000057913 0248_ $$2sideral$$a87873
000057913 037__ $$aART-2014-87873
000057913 041__ $$aeng
000057913 100__ $$0(orcid)0000-0001-5193-7782$$aCalvo Royo, Ana Cristina$$uUniversidad de Zaragoza
000057913 245__ $$aAmyotrophic Lateral Sclerosis: A Focus on Disease Progression
000057913 260__ $$c2014
000057913 5060_ $$aAccess copy available to the general public$$fUnrestricted
000057913 5203_ $$aSince amyotrophic lateral sclerosis (ALS) was discovered and described in 1869 as a neurodegenerative disease in which motor neuron death is induced, a wide range of biomarkers have been selected to identify therapeutic targets. ALS shares altered molecular pathways with other neurodegenerative diseases, such as Alzheimer’s, Huntington’s, and Parkinson’s diseases. However, the molecular targets that directly influence its aggressive nature remain unknown.What is the first link in the neurodegenerative chain of ALS that makes this disease so peculiar? In this review, we will discuss the progression of the disease from the viewpoint of the potential biomarkers described to date in human and animal model samples. Finally, we will consider potential therapeutic strategies for ALS treatment and future, innovative perspectives.
000057913 536__ $$9info:eu-repo/grantAgreement/ES/FIS/PI10-0178$$9info:eu-repo/grantAgreement/ES/UZ/UZ2012-BIO-02-210-155
000057913 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000057913 590__ $$a1.579$$b2014
000057913 591__ $$aMEDICINE, RESEARCH & EXPERIMENTAL$$b85 / 123 = 0.691$$c2014$$dQ3$$eT3
000057913 591__ $$aBIOTECHNOLOGY & APPLIED MICROBIOLOGY$$b106 / 162 = 0.654$$c2014$$dQ3$$eT2
000057913 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000057913 700__ $$aManzano, Raquel
000057913 700__ $$aMendonça, Deise M.F.
000057913 700__ $$aMuñoz, María Jesús
000057913 700__ $$aZaragoza, Pilar
000057913 700__ $$aOsta, Rosario
000057913 7102_ $$11001$$2420$$aUniversidad de Zaragoza$$bDepartamento de Anatomía, Embriología y Genética Animal$$cGenética
000057913 773__ $$g2014 (2014), 925101 [12 pp]$$pBioMed res. int.$$tBioMed Research International$$x2314-6133
000057913 8564_ $$s762433$$uhttps://zaguan.unizar.es/record/57913/files/texto_completo.pdf$$yVersión publicada
000057913 8564_ $$s101985$$uhttps://zaguan.unizar.es/record/57913/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000057913 909CO $$ooai:zaguan.unizar.es:57913$$particulos$$pdriver
000057913 951__ $$a2016-12-16-14:53:52
000057913 980__ $$aARTICLE