57913 20201023135900.0 doi 10.1155/2014/925101 sideral 87873 ART-2014-87873 eng (orcid)0000-0001-5193-7782 Calvo Royo, Ana Cristina Universidad de Zaragoza Amyotrophic Lateral Sclerosis: A Focus on Disease Progression 2014 Access copy available to the general public Unrestricted Since amyotrophic lateral sclerosis (ALS) was discovered and described in 1869 as a neurodegenerative disease in which motor neuron death is induced, a wide range of biomarkers have been selected to identify therapeutic targets. ALS shares altered molecular pathways with other neurodegenerative diseases, such as Alzheimer’s, Huntington’s, and Parkinson’s diseases. However, the molecular targets that directly influence its aggressive nature remain unknown.What is the first link in the neurodegenerative chain of ALS that makes this disease so peculiar? In this review, we will discuss the progression of the disease from the viewpoint of the potential biomarkers described to date in human and animal model samples. Finally, we will consider potential therapeutic strategies for ALS treatment and future, innovative perspectives. info:eu-repo/grantAgreement/ES/FIS/PI10-0178 info:eu-repo/grantAgreement/ES/UZ/UZ2012-BIO-02-210-155 info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 1.579 2014 MEDICINE, RESEARCH & EXPERIMENTAL 85 / 123 = 0.691 2014 Q3 T3 BIOTECHNOLOGY & APPLIED MICROBIOLOGY 107 / 163 = 0.656 2014 Q3 T2 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Manzano, Raquel Mendonça, Deise M.F. Muñoz, María Jesús Zaragoza, Pilar Osta, Rosario 1001 420 Universidad de Zaragoza Dpto. Anatom.,Embri.Genét.Ani. Área Genética 2014 (2014), 925101 [12 pp] BioMed res. int. BioMed Research International 2314-6133 762433 http://zaguan.unizar.es/record/57913/files/texto_completo.pdf Versión publicada 101985 http://zaguan.unizar.es/record/57913/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:57913 articulos driver 2020-10-23-13:53:36 ARTICLE