000057919 001__ 57919 000057919 005__ 20230421130004.0 000057919 0247_ $$2doi$$a10.1186/1471-2377-13-165 000057919 0248_ $$2sideral$$a84286 000057919 037__ $$aART-2013-84286 000057919 041__ $$aeng 000057919 100__ $$aSachdev, P.S. 000057919 245__ $$aCOSMIC (Cohort Studies of Memory in an International Consortium): An international consortium to identify risk and protective factors and biomarkers of cognitive ageing and dementia in diverse ethnic and sociocultural groups 000057919 260__ $$c2013 000057919 5060_ $$aAccess copy available to the general public$$fUnrestricted 000057919 5203_ $$aBackground: A large number of longitudinal studies of population-based ageing cohorts are in progress internationally, but the insights from these studies into the risk and protective factors for cognitive ageing and conditions like mild cognitive impairment and dementia have been inconsistent. Some of the problems confounding this research can be reduced by harmonising and pooling data across studies. COSMIC (Cohort Studies of Memory in an International Consortium) aims to harmonise data from international cohort studies of cognitive ageing, in order to better understand the determinants of cognitive ageing and neurocognitive disorders. Methods/Design: Longitudinal studies of cognitive ageing and dementia with at least 500 individuals aged 60 years or over are eligible and invited to be members of COSMIC. There are currently 17 member studies, from regions that include Asia, Australia, Europe, and North America. A Research Steering Committee has been established, two meetings of study leaders held, and a website developed. The initial attempts at harmonising key variables like neuropsychological test scores are in progress. Discussion: The challenges of international consortia like COSMIC include efficient communication among members, extended use of resources, and data harmonisation. Successful harmonisation will facilitate projects investigating rates of cognitive decline, risk and protective factors for mild cognitive impairment, and biomarkers of mild cognitive impairment and dementia. Extended implications of COSMIC could include standardised ways of collecting and reporting data, and a rich cognitive ageing database being made available to other researchers. COSMIC could potentially transform our understanding of the epidemiology of cognitive ageing, and have a world-wide impact on promoting successful ageing. 000057919 536__ $$9info:eu-repo/grantAgreement/ES/ISCIII/FIS/98-0103$$9info:eu-repo/grantAgreement/ES/ISCIII/FIS/97-1321E$$9info:eu-repo/grantAgreement/ES/ISCIII/FIS/94-1562$$9info:eu-repo/grantAgreement/ES/ISCIII/FIS/06-0617$$9info:eu-repo/grantAgreement/ES/ISCIII/FIS/03-0815$$9info:eu-repo/grantAgreement/ES/ISCIII/FIS/01-0255$$9info:eu-repo/grantAgreement/ES/ISCIII/FIS/G03-128 000057919 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/ 000057919 590__ $$a2.486$$b2013 000057919 591__ $$aCLINICAL NEUROLOGY$$b82 / 192 = 0.427$$c2013$$dQ2$$eT2 000057919 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion 000057919 700__ $$aLipnicki, D.M. 000057919 700__ $$aKochan, N.A. 000057919 700__ $$aCrawford, J.D. 000057919 700__ $$aRockwood, K. 000057919 700__ $$aXiao, S. 000057919 700__ $$aLi, J. 000057919 700__ $$aLi, X. 000057919 700__ $$aBrayne, C. 000057919 700__ $$aMatthews, F.E. 000057919 700__ $$aStephan, B.C.M. 000057919 700__ $$aLipton, R.B. 000057919 700__ $$aKatz, M.J. 000057919 700__ $$aRitchie, K. 000057919 700__ $$aCarrière, I. 000057919 700__ $$aAncelin, M.L. 000057919 700__ $$aSeshadri, S. 000057919 700__ $$aAu, R. 000057919 700__ $$aBeiser, A.S. 000057919 700__ $$aLam, L.C.W. 000057919 700__ $$aWong, C.H.Y. 000057919 700__ $$aFung, A.W.T. 000057919 700__ $$aKim, K.W. 000057919 700__ $$aHan, J.W. 000057919 700__ $$aKim, T.H. 000057919 700__ $$aPetersen, R.C. 000057919 700__ $$aRoberts, R.O. 000057919 700__ $$aMielke, M.M. 000057919 700__ $$aGanguli, M. 000057919 700__ $$aDodge, H.H. 000057919 700__ $$aHughes, T. 000057919 700__ $$aAnstey, K.J. 000057919 700__ $$aCherbuin, N. 000057919 700__ $$aButterworth, P. 000057919 700__ $$aNg, T.P. 000057919 700__ $$aGao, Q. 000057919 700__ $$aReppermund, S. 000057919 700__ $$aBrodaty, H. 000057919 700__ $$aMeguro, K. 000057919 700__ $$aSchupf, N. 000057919 700__ $$aManly, J. 000057919 700__ $$aStern, Y. 000057919 700__ $$0(orcid)0000-0002-9098-655X$$aLobo, A.$$uUniversidad de Zaragoza 000057919 700__ $$0(orcid)0000-0002-3360-7015$$aLopez-Anton, R.$$uUniversidad de Zaragoza 000057919 700__ $$0(orcid)0000-0002-7297-6104$$aSantabarbara, J.$$uUniversidad de Zaragoza 000057919 7102_ $$14009$$2730$$aUniversidad de Zaragoza$$bDpto. Psicología y Sociología$$cÁrea Psicología Básica 000057919 7102_ $$11007$$2745$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Psiquiatría 000057919 7102_ $$11008$$2615$$aUniversidad de Zaragoza$$bDpto. Microb.Med.Pr.,Sal.Públ.$$cÁrea Medic.Prevent.Salud Públ. 000057919 773__ $$g13 (2013), 165 [8 pp]$$pBMC neurol.$$tBMC Neurology$$x1471-2377 000057919 8564_ $$s304219$$uhttps://zaguan.unizar.es/record/57919/files/texto_completo.pdf$$yVersión publicada 000057919 8564_ $$s89265$$uhttps://zaguan.unizar.es/record/57919/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada 000057919 909CO $$ooai:zaguan.unizar.es:57919$$particulos$$pdriver 000057919 951__ $$a2023-04-21-12:38:16 000057919 980__ $$aARTICLE