000057920 001__ 57920
000057920 005__ 20170327111930.0
000057920 0247_ $$2doi$$a10.1155/2014/179070
000057920 0248_ $$2sideral$$a85898
000057920 037__ $$aART-2014-85898
000057920 041__ $$aeng
000057920 100__ $$0(orcid)0000-0002-6305-9283$$aManzano, Sara$$uUniversidad de Zaragoza
000057920 245__ $$aCartilage Dysfunction in ALS Patients as Side Effect of Motion Loss: 3D Mechano-Electrochemical Computational Model
000057920 260__ $$c2014
000057920 5060_ $$aAccess copy available to the general public$$fUnrestricted
000057920 5203_ $$aAmyotrophic lateral sclerosis (ALS) is a debilitating motor neuron disease characterized by progressive weakness, muscle atrophy, and fasciculation. This fact results in a continuous degeneration and dysfunction of articular soft tissues. Specifically, cartilage is an avascular and nonneural connective tissue that allows smooth motion in diarthrodial joints. Due to the avascular nature of cartilage tissue, cells nutrition and by-product exchange are intermittently occurring during joint motions. Reduced mobility results in a change of proteoglycan density, osmotic pressure, and permeability of the tissue. This work aims to demonstrate the abnormal cartilage deformation in progressive immobilized articular cartilage for ALS patients. For this aim a novel 3D mechano-electrochemical model based on the triphasic theory for charged hydrated soft tissues is developed. ALS patient parameters such as tissue porosity, osmotic coefficient, and fixed anions were incorporated. Considering different mobility reduction of each phase of the disease, results predicted the degree of tissue degeneration and the reduction of its capacity for deformation. The present model can be a useful tool to predict the evolution of joints in ALS patients and the necessity of including specific cartilage protectors, drugs, or maintenance physical activities as part of the symptomatic treatment in amyotrophic lateral sclerosis.
000057920 536__ $$9info:eu-repo/grantAgreement/ES/CICYT/DPI2010-20399-C04-01$$9info:eu-repo/grantAgreement/ES/MEC/FPU-AP2010-2557
000057920 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000057920 590__ $$a1.579$$b2014
000057920 591__ $$aMEDICINE, RESEARCH & EXPERIMENTAL$$b85 / 123 = 0.691$$c2014$$dQ3$$eT3
000057920 591__ $$aBIOTECHNOLOGY & APPLIED MICROBIOLOGY$$b106 / 162 = 0.654$$c2014$$dQ3$$eT2
000057920 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000057920 700__ $$aGaffney, Eamonn A.
000057920 700__ $$0(orcid)0000-0001-8741-6452$$aDoblaré, Manuel$$uUniversidad de Zaragoza
000057920 700__ $$0(orcid)0000-0003-0088-7222$$aHamdy Doweidar, Mohamed$$uUniversidad de Zaragoza
000057920 7102_ $$15004$$2605$$aUniversidad de Zaragoza$$bDepartamento de Ingeniería Mecánica$$cMec. de Medios Contínuos y Teor. de Estructuras
000057920 773__ $$g2014 (2014), 179070 [13 pp]$$pBioMed res. int.$$tBioMed Research International$$x2314-6133
000057920 8564_ $$s3475611$$uhttps://zaguan.unizar.es/record/57920/files/texto_completo.pdf$$yVersión publicada
000057920 8564_ $$s98882$$uhttps://zaguan.unizar.es/record/57920/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000057920 909CO $$ooai:zaguan.unizar.es:57920$$particulos$$pdriver
000057920 951__ $$a2016-12-16-14:54:23
000057920 980__ $$aARTICLE