57920 20170327111930.0 doi 10.1155/2014/179070 sideral 85898 ART-2014-85898 eng (orcid)0000-0002-6305-9283 Manzano, Sara Universidad de Zaragoza Cartilage Dysfunction in ALS Patients as Side Effect of Motion Loss: 3D Mechano-Electrochemical Computational Model 2014 Access copy available to the general public Unrestricted Amyotrophic lateral sclerosis (ALS) is a debilitating motor neuron disease characterized by progressive weakness, muscle atrophy, and fasciculation. This fact results in a continuous degeneration and dysfunction of articular soft tissues. Specifically, cartilage is an avascular and nonneural connective tissue that allows smooth motion in diarthrodial joints. Due to the avascular nature of cartilage tissue, cells nutrition and by-product exchange are intermittently occurring during joint motions. Reduced mobility results in a change of proteoglycan density, osmotic pressure, and permeability of the tissue. This work aims to demonstrate the abnormal cartilage deformation in progressive immobilized articular cartilage for ALS patients. For this aim a novel 3D mechano-electrochemical model based on the triphasic theory for charged hydrated soft tissues is developed. ALS patient parameters such as tissue porosity, osmotic coefficient, and fixed anions were incorporated. Considering different mobility reduction of each phase of the disease, results predicted the degree of tissue degeneration and the reduction of its capacity for deformation. The present model can be a useful tool to predict the evolution of joints in ALS patients and the necessity of including specific cartilage protectors, drugs, or maintenance physical activities as part of the symptomatic treatment in amyotrophic lateral sclerosis. info:eu-repo/grantAgreement/ES/CICYT/DPI2010-20399-C04-01 info:eu-repo/grantAgreement/ES/MEC/FPU-AP2010-2557 info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 1.579 2014 MEDICINE, RESEARCH & EXPERIMENTAL 85 / 123 = 0.691 2014 Q3 T3 BIOTECHNOLOGY & APPLIED MICROBIOLOGY 106 / 162 = 0.654 2014 Q3 T2 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Gaffney, Eamonn A. (orcid)0000-0001-8741-6452 Doblaré, Manuel Universidad de Zaragoza (orcid)0000-0003-0088-7222 Hamdy Doweidar, Mohamed Universidad de Zaragoza 5004 605 Universidad de Zaragoza Departamento de Ingeniería Mecánica Mec. de Medios Contínuos y Teor. de Estructuras 2014 (2014), 179070 [13 pp] BioMed res. int. BioMed Research International 2314-6133 3475611 http://zaguan.unizar.es/record/57920/files/texto_completo.pdf Versión publicada 98882 http://zaguan.unizar.es/record/57920/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:57920 articulos driver 2016-12-16-14:54:23 ARTICLE