000057922 001__ 57922
000057922 005__ 20180122145903.0
000057922 0247_ $$2doi$$a10.1155/2013/906572
000057922 0248_ $$2sideral$$a82908
000057922 037__ $$aART-2013-82908
000057922 041__ $$aeng
000057922 100__ $$aTondo, M.L.
000057922 245__ $$aCrystal structure of the FAD-containing ferredoxin-NADP+ reductase from the plant pathogen Xanthomonas axonopodis pv. citri
000057922 260__ $$c2013
000057922 5060_ $$aAccess copy available to the general public$$fUnrestricted
000057922 5203_ $$aWe have solved the structure of ferredoxin-NADP(H) reductase, FPR, from the plant pathogen Xanthomonas axonopodis pv. citri, responsible for citrus canker, at a resolution of 1.5¿Å. This structure reveals differences in the mobility of specific loops when compared to other FPRs, probably unrelated to the hydride transfer process, which contributes to explaining the structural and functional divergence between the subclass I FPRs. Interactions of the C-terminus of the enzyme with the phosphoadenosine of the cofactor FAD limit its mobility, thus affecting the entrance of nicotinamide into the active site. This structure opens the possibility of rationally designing drugs against the X. axonopodis pv. citri phytopathogen.
000057922 536__ $$9info:eu-repo/grantAgreement/ES/DGA/B18$$9info:eu-repo/grantAgreement/ES/MICINN/BIO2010-14983
000057922 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000057922 590__ $$a0.0$$b2013
000057922 591__ $$aMEDICINE, RESEARCH & EXPERIMENTAL
000057922 591__ $$aBIOTECHNOLOGY & APPLIED MICROBIOLOGY
000057922 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000057922 700__ $$0(orcid)0000-0002-3122-9401$$aHurtado-Guerrero, R.
000057922 700__ $$aCeccarelli, E.A.
000057922 700__ $$0(orcid)0000-0001-8743-0182$$aMedina, M.$$uUniversidad de Zaragoza
000057922 700__ $$aOrellano, E.G.
000057922 700__ $$0(orcid)0000-0001-9047-0046$$aMartínez-Júlvez, M.$$uUniversidad de Zaragoza
000057922 7102_ $$11002$$2060$$aUniversidad de Zaragoza$$bDepartamento de Bioquímica y Biología Molecular y Celular$$cBioquímica y Biología Molecular
000057922 773__ $$g2013, 906572 (2013), [6 pp.]$$pBioMed res. int.$$tBioMed Research International$$x2314-6133
000057922 8564_ $$s2004190$$uhttps://zaguan.unizar.es/record/57922/files/texto_completo.pdf$$yVersión publicada
000057922 8564_ $$s95161$$uhttps://zaguan.unizar.es/record/57922/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000057922 909CO $$ooai:zaguan.unizar.es:57922$$particulos$$pdriver
000057922 951__ $$a2018-01-22-14:58:33
000057922 980__ $$aARTICLE