Shape matters: Synthesis and biomedical applications of high aspect ratio magnetic nanomaterials

Fratila, R.M. (Universidad de Zaragoza) ; Rivera-Fernández, S. ; de la Fuente, J.M. (Universidad de Zaragoza)

Resumen: High aspect ratio magnetic nanomaterials possess anisotropic properties that make them attractive for biological applications. Their elongated shape enables multivalent interactions with receptors through the introduction of multiple targeting units on their surface, thus enhancing cell internalization. Moreover, due to their magnetic anisotropy, high aspect ratio nanomaterials can outperform their spherical analogues as contrast agents for magnetic resonance imaging (MRI) applications. In this review, we first describe the two main synthetic routes for the preparation of anisotropic magnetic nanomaterials: (i) direct synthesis (in which the anisotropic growth is directed by tuning the reaction conditions or by using templates) and (ii) assembly methods (in which the high aspect ratio is achieved by assembly from individual building blocks). We then provide an overview of the biomedical applications of anisotropic magnetic nanomaterials: magnetic separation and detection, targeted delivery and magnetic resonance imaging.

Idioma: Inglés

DOI: 10.1039/c5nr01100k

Año: 2015

Publicado en: Nanoscale 7, 18 (2015), 8233-8260
ISSN: 2040-3364

Factor impacto JCR: 7.76 (2015)

Categ. JCR: MATERIALS SCIENCE, MULTIDISCIPLINARY rank: 23 / 271 = 0.085 (2015) - Q1 - T1
Categ. JCR: NANOSCIENCE & NANOTECHNOLOGY rank: 12 / 83 = 0.145 (2015) - Q1 - T1
Categ. JCR: CHEMISTRY, MULTIDISCIPLINARY rank: 18 / 163 = 0.11 (2015) - Q1 - T1
Categ. JCR: PHYSICS, APPLIED rank: 12 / 145 = 0.083 (2015) - Q1 - T1

Factor impacto SCIMAGO: 2.77 - Nanoscience and Nanotechnology (Q1) - Materials Science (miscellaneous) (Q1)

Financiación: info:eu-repo/grantAgreement/EC/FP7/239931/EU/Multifunctional Magnetic Nanoparticles: Towards Smart Drugs Design/NANOPUZZLE

Tipo y forma: Artículo (PostPrint)

Área (Departamento): Área Química Orgánica (Dpto. Química Orgánica)