58351 20230126102832.0 doi 10.1039/c4nr01588f sideral 87027 ART-2014-87027 eng Urries, I. (orcid)0000-0001-6727-8187 Magneto-plasmonic nanoparticles as theranostic platforms for magnetic resonance imaging, drug delivery and NIR hyperthermia applications 2014 Access copy available to the general public Unrestricted PEGylated magneto-plasmonic nanoparticles with a hollow or semi-hollow interior have been successfully synthesized and their physico-chemical characteristics have been investigated. The hollow interior space can be used to store drugs or other molecules of interest whereas magnetic characterization shows their potential as contrast agents in magnetic resonance imaging (MRI) applications. In addition, their plasmonic characteristics in the near infrared (NIR) region make them efficient in photothermal applications producing high temperature gradients after short irradiation times. We show that by controlling the etching conditions the inner silica shell can be selectively dissolved to achieve a hollow or semi-hollow interior without compromising the magnetic or plasmonic characteristics of the resulting nanoparticles. Magnetic measurements and transmission electron microscopy observations have been used to demonstrate the precise control during the etching process and to select an optimal concentration of the etching reagent and contact time to preserve the inner superparamagnetic iron oxide-based nanoparticles and the plasmonic properties of the constructs. Drug loading capabilities were also evaluated for both semi-hollow and as-synthesized nanoparticles using Rhodamine B isothiocyanate as a model compound. The nanoparticles produced could be potentially used as “theranostic” nanoparticles with both imaging capabilities and a dual therapeutic function (drug delivery and hyperthermia). info:eu-repo/grantAgreement/EC/FP7/321642/EU/Development of a microfluidic platform to produce nanomaterials and assessment on new nanotechnology applications/PLATFORM2NANO info:eu-repo/grantAgreement/ES/MICINN/MAT2011-24988 info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 7.394 2014 MATERIALS SCIENCE, MULTIDISCIPLINARY 21 / 260 = 0.081 2014 Q1 T1 NANOSCIENCE & NANOTECHNOLOGY 10 / 80 = 0.125 2014 Q1 T1 CHEMISTRY, MULTIDISCIPLINARY 19 / 157 = 0.121 2014 Q1 T1 PHYSICS, APPLIED 12 / 144 = 0.083 2014 Q1 T1 info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion Muñoz, C. Gomez, L. Universidad de Zaragoza (orcid)0000-0001-6971-5192 Marquina, C. Universidad de Zaragoza (orcid)0000-0003-0602-492X Sebastian, V. Universidad de Zaragoza (orcid)0000-0002-6873-5244 Arruebo, M. Universidad de Zaragoza (orcid)0000-0003-3165-0156 Santamaria, J. Universidad de Zaragoza (orcid)0000-0002-8701-9745 5005 555 Universidad de Zaragoza Dpto. Ing.Quím.Tecnol.Med.Amb. Área Ingeniería Química 2003 395 Universidad de Zaragoza Dpto. Física Materia Condensa. Área Física Materia Condensada 6, 15 (2014), 9230-9240 Nanoscale Nanoscale 2040-3364 1458517 http://zaguan.unizar.es/record/58351/files/texto_completo.pdf Postprint 111417 http://zaguan.unizar.es/record/58351/files/texto_completo.jpg?subformat=icon icon Postprint oai:zaguan.unizar.es:58351 articulos driver 2023-01-26-09:51:01 ARTICLE