000058459 001__ 58459
000058459 005__ 20200221144228.0
000058459 0247_ $$2doi$$a10.1186/s12890-016-0305-2
000058459 0248_ $$2sideral$$a97459
000058459 037__ $$aART-2016-97459
000058459 041__ $$aeng
000058459 100__ $$aEspantoso-Romero, M.
000058459 245__ $$aExternal validation of multidimensional prognostic indices (ADO, BODEx and DOSE) in a primary care international cohort (PROEPOC/COPD cohort)
000058459 260__ $$c2016
000058459 5060_ $$aAccess copy available to the general public$$fUnrestricted
000058459 5203_ $$aBackground: Due to the heterogeneous and systemic nature of the chronic obstructive pulmonary disease (COPD), the new guidelines are oriented toward individualized attention. Multidimensional scales could facilitate its proper clinical and prognostic assessment, but not all of them were validated in an international primary care cohort, different from the original ones used for model development. Therefore, our main aim is to assess the prognostic capacity of the ADO, BODEx and DOSE indices in primary care for predicting mortality in COPD patients and to validate the models obtained in subgroups of patients, classified by revised Global Initiative for Chronic Obstructive Lung Disease (2011) and updated Spanish Guideline (2014). Besides, we want to confirm that the prognostic capacity of all indices increases if the number of exacerbations is substituted by the interval between them and to assess the impact on health of the patient''s lifestyle, social network and adherence to treatment. Methods: Design: External validation of scales, open and prospective cohort study in primary care. Setting: 36 health centres in 6 European high, medium and low income countries. Subjects: 477 patients diagnosed with COPD, captured in clinical visit by their General Practitioner/Nurse. Predictors: Detailed patient history, exacerbations, lung function test and questionnaires at baseline. Outcomes: Exacerbations, all-cause mortality and specific mortality, within 5 years of recruitment. Analysis: Multivariate logistic regression and Cox regression will be used. Possible non-linear effect of the indices will be studied by using Structured Additive Regression models with penalised splines. Subsequently, we will assess different aspects of the regression models: discrimination, calibration and diagnostic precision. Clinical variables modulated in primary care and the interval between exacerbations will be considered and incorporated into the analysis. Discussion: The Research Agenda for General Practice/Family Medicine highlights that the evidence on predictive values of prognostic indices in primary care is scarce. A prospective cohort like that of PROEPOC/COPD provides good opportunities for research into COPD and make communication easier between family practitioners, nursing staff, pneumologists and other professionals, supporting a multi-disciplinary approach to the treatment of these patients. Trial registration:ISRCTN52402811. Date: 15/01/2015. Prospectively registered.
000058459 536__ $$9info:eu-repo/grantAgreement/ES/ISCIII/PI14-00385
000058459 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000058459 590__ $$a2.435$$b2016
000058459 591__ $$aRESPIRATORY SYSTEM$$b34 / 59 = 0.576$$c2016$$dQ3$$eT2
000058459 592__ $$a1.161$$b2016
000058459 593__ $$aPulmonary and Respiratory Medicine$$c2016$$dQ1
000058459 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000058459 700__ $$aRomán Rodríguez, M.
000058459 700__ $$aDuarte-Pérez, A.
000058459 700__ $$aGonzálvez-Rey, J.
000058459 700__ $$aCallejas-Cabanillas, P.
000058459 700__ $$aLazic, D.K.
000058459 700__ $$aAnta-Agudo, B.
000058459 700__ $$aTorán Monserrat, P.
000058459 700__ $$0(orcid)0000-0002-5494-6550$$aMagallon-Botaya, R.$$uUniversidad de Zaragoza
000058459 700__ $$aGerasimovska Kitanovska, B.
000058459 700__ $$aLingner, H.
000058459 700__ $$aAssenova, R.S.
000058459 700__ $$aIftode, C.
000058459 700__ $$aGude-Sampedro, F.
000058459 700__ $$aClavería, A.
000058459 700__ $$aAbalde-Castro, L.
000058459 700__ $$aAres-Vila, S.
000058459 700__ $$aBernardez-Peña, L.N.
000058459 700__ $$aBozhinovska, E.
000058459 700__ $$aBudiu, I.
000058459 700__ $$aBundó Vidiella, M.
000058459 700__ $$aClemente-Jimenez, L.
000058459 700__ $$aComa Carbó, R.M.
000058459 700__ $$aDel Río-Navarro, C.
000058459 700__ $$aErazo, S.
000058459 700__ $$aGóngora Andrades, M.A.
000058459 700__ $$aGorreto López, L.
000058459 700__ $$aHamulka, D.
000058459 700__ $$aHernández-Rodríguez, A.
000058459 700__ $$aHristeva Foreva, G.
000058459 700__ $$aJovanovska, S.
000058459 700__ $$aLazic, A.
000058459 700__ $$aMartín-Campos, C.
000058459 700__ $$aMayrata, A.
000058459 700__ $$aMontero Alia, P.
000058459 700__ $$aNegrete Palma, A.
000058459 700__ $$aNúñez-Chicharro, L.
000058459 700__ $$aPadure, I.
000058459 700__ $$aPalmer Simó, J.F.
000058459 700__ $$aPérez-Villar, M.V.
000058459 700__ $$aRego-Sieiro, E.
000058459 700__ $$aRobles Sánchez, C.
000058459 700__ $$aRodríguez-Reneda, L.
000058459 700__ $$aSchmiemann, G.
000058459 700__ $$aSorribes Lopez, J.
000058459 700__ $$aSpasovska, A.
000058459 700__ $$aStanic, J.
000058459 700__ $$aStefanescu, S.
000058459 700__ $$aTiljak, A.
000058459 700__ $$aValero Suau, A.
000058459 700__ $$aVila Rigat, R.
000058459 700__ $$aVolkenand, K.
000058459 700__ $$aWöbkenberg, J.
000058459 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina
000058459 773__ $$g16, 143 (2016), [9 pp.]$$pBMC polm. med.$$tBMC pulmonary medicine$$x1471-2466
000058459 8564_ $$s486048$$uhttps://zaguan.unizar.es/record/58459/files/texto_completo.pdf$$yVersión publicada
000058459 8564_ $$s86122$$uhttps://zaguan.unizar.es/record/58459/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
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000058459 951__ $$a2020-02-21-13:18:22
000058459 980__ $$aARTICLE