000058475 001__ 58475 000058475 005__ 20200221144348.0 000058475 0247_ $$2doi$$a10.1371/journal.pone.0167400 000058475 0248_ $$2sideral$$a97574 000058475 037__ $$aART-2016-97574 000058475 041__ $$aeng 000058475 100__ $$aRosell-Negre, P. 000058475 245__ $$aReward contingencies improve goal-directed behavior by enhancing posterior brain attentional regions and increasing corticostriatal connectivity in cocaine addicts 000058475 260__ $$c2016 000058475 5060_ $$aAccess copy available to the general public$$fUnrestricted 000058475 5203_ $$aThe dopaminergic system provides the basis for the interaction between motivation and cognition. It is triggered by the possibility of obtaining rewards to initiate the neurobehavioral adaptations necessary to achieve them by directing the information from motivational circuits to cognitive and action circuits. In drug addiction, the altered dopamine (DA) modulation of the meso-cortico-limbic reward circuitry, such as the prefrontal cortex (PFC), underlies the disproportionate motivational value of drug use at the expense of other nondrug reinforcers and the user''s loss of control over his/her drug intake. We examine how the magnitude of the reward affects goal-directed processes in healthy control (HC) subjects and abstinent cocaine dependent (ACD) patients by using functional magnetic resonance imaging (fMRI) during a counting Stroop task with blocked levels of monetary incentives of different magnitudes (€0, €0.01, €0.5, €1 or €1.5). Our results showed that increasing reward magnitude enhances (1) performance facilitation in both groups; (2) left dorsolateral prefrontal cortex (DLPFC) activity in HC and left superior occipital cortex activity in ACD; and (3) left DLPFC and left putamen connectivity in ACD compared to HC. Moreover, we observed that (4) dorsal striatal and pallidum activity was associated with craving and addiction severity during the parametric increases in the monetary reward. In conclusion, the brain response to gradients in monetary value was different in HC and ACD, but both groups showed improved task performance due to the possibility of obtaining greater monetary rewards. 000058475 536__ $$9info:eu-repo/grantAgreement/ES/MINECO/PSI2012-33054$$9info:eu-repo/grantAgreement/ES/PND/2011I040 000058475 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/ 000058475 590__ $$a2.806$$b2016 000058475 591__ $$aMULTIDISCIPLINARY SCIENCES$$b15 / 63 = 0.238$$c2016$$dQ1$$eT1 000058475 592__ $$a1.236$$b2016 000058475 593__ $$aAgricultural and Biological Sciences (miscellaneous)$$c2016$$dQ1 000058475 593__ $$aMedicine (miscellaneous)$$c2016$$dQ1 000058475 593__ $$aBiochemistry, Genetics and Molecular Biology (miscellaneous)$$c2016$$dQ1 000058475 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion 000058475 700__ $$0(orcid)0000-0002-8201-0469$$aBustamante, J.C.$$uUniversidad de Zaragoza 000058475 700__ $$aFuentes-Claramonte, P. 000058475 700__ $$aCostumero, V. 000058475 700__ $$aLlopis-Llacer, J. 000058475 700__ $$aBarrós-Loscertales, A. 000058475 7102_ $$14009$$2735$$aUniversidad de Zaragoza$$bDpto. Psicología y Sociología$$cÁrea Psicolog.Evolut.Educac 000058475 773__ $$g11, 12 (2016), 0167400[22pp]$$pPLoS One$$tPloS one$$x1932-6203 000058475 8564_ $$s776635$$uhttps://zaguan.unizar.es/record/58475/files/texto_completo.pdf$$yVersión publicada 000058475 8564_ $$s74291$$uhttps://zaguan.unizar.es/record/58475/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada 000058475 909CO $$ooai:zaguan.unizar.es:58475$$particulos$$pdriver 000058475 951__ $$a2020-02-21-13:53:46 000058475 980__ $$aARTICLE