000058478 001__ 58478
000058478 005__ 20200221144319.0
000058478 0247_ $$2doi$$a10.1038/srep38733
000058478 0248_ $$2sideral$$a97587
000058478 037__ $$aART-2016-97587
000058478 041__ $$aeng
000058478 100__ $$0(orcid)0000-0002-5578-7635$$aSanz, B.
000058478 245__ $$aIn silico before in vivo: How to predict the heating efficiency of magnetic nanoparticles within the intracellular space
000058478 260__ $$c2016
000058478 5060_ $$aAccess copy available to the general public$$fUnrestricted
000058478 5203_ $$aThis work aims to demonstrate the need for in silico design via numerical simulation to produce optimal Fe 3 O 4 -based magnetic nanoparticles (MNPs) for magnetic hyperthermia by minimizing the impact of intracellular environments on heating efficiency. By including the relevant magnetic parameters, such as magnetic anisotropy and dipolar interactions, into a numerical model, the heating efficiency of as prepared colloids was preserved in the intracellular environment, providing the largest in vitro specific power absorption (SPA) values yet reported. Dipolar interactions due to intracellular agglomeration, which are included in the simulated SPA, were found to be the main cause of changes in the magnetic relaxation dynamics of MNPs under in vitro conditions. These results pave the way for the magnetism-based design of MNPs that can retain their heating efficiency in vivo, thereby improving the outcome of clinical hyperthermia experiments.
000058478 536__ $$9info:eu-repo/grantAgreement/ES/MINECO/MAT2013-42551
000058478 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000058478 590__ $$a4.259$$b2016
000058478 591__ $$aMULTIDISCIPLINARY SCIENCES$$b10 / 63 = 0.159$$c2016$$dQ1$$eT1
000058478 592__ $$a1.691$$b2016
000058478 593__ $$aMultidisciplinary$$c2016$$dQ1
000058478 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000058478 700__ $$0(orcid)0000-0001-9359-0019$$aCalatayud, M.P.
000058478 700__ $$aDe Biasi, E.
000058478 700__ $$aLima, E.
000058478 700__ $$aMansilla, M.V.
000058478 700__ $$aZysler, R.D.
000058478 700__ $$aIbarra, M.R.
000058478 700__ $$aGoya, G.F.
000058478 773__ $$g6 (2016), 38733 [10 pp]$$pSci. rep.$$tSCIENTIFIC REPORTS$$x2045-2322
000058478 8564_ $$s411792$$uhttps://zaguan.unizar.es/record/58478/files/texto_completo.pdf$$yVersión publicada
000058478 8564_ $$s111734$$uhttps://zaguan.unizar.es/record/58478/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000058478 909CO $$ooai:zaguan.unizar.es:58478$$particulos$$pdriver
000058478 951__ $$a2020-02-21-13:40:36
000058478 980__ $$aARTICLE