000058481 001__ 58481
000058481 005__ 20200221144318.0
000058481 0247_ $$2doi$$a10.1038/ncomms13507
000058481 0248_ $$2sideral$$a97605
000058481 037__ $$aART-2016-97605
000058481 041__ $$aeng
000058481 100__ $$aVentham, N.T.
000058481 245__ $$aIntegrative epigenome-wide analysis demonstrates that DNA methylation may mediate genetic risk in inflammatory bowel disease
000058481 260__ $$c2016
000058481 5060_ $$aAccess copy available to the general public$$fUnrestricted
000058481 5203_ $$aEpigenetic alterations may provide important insights into gene-environment interaction in inflammatory bowel disease (IBD). Here we observe epigenome-wide DNA methylation differences in 240 newly-diagnosed IBD cases and 190 controls. These include 439 differentially methylated positions (DMPs) and 5 differentially methylated regions (DMRs), which we study in detail using whole genome bisulphite sequencing. We replicate the top DMP (RPS6KA2) and DMRs (VMP1, ITGB2 and TXK) in an independent cohort. Using paired genetic and epigenetic data, we delineate methylation quantitative trait loci; VMP1/microRNA-21 methylation associates with two polymorphisms in linkage disequilibrium with a known IBD susceptibility variant. Separated cell data shows that IBD-associated hypermethylation within the TXK promoter region negatively correlates with gene expression in whole-blood and CD8+ T cells, but not other cell types. Thus, site-specific DNA methylation changes in IBD relate to underlying genotype and associate with cell-specific alteration in gene expression.
000058481 536__ $$9info:eu-repo/grantAgreement/EC/FP7/305676/EU/Inflammatory Bowel Disease CHARACTERization by a multi-modal integrated biomarker study/IBD-CHARACTER$$9info:eu-repo/grantAgreement/EC/FP7/305479/EU/Diagnostic and prognostic biomarkers for inflammatory bowel diseaseIBD-BIOM/IBD-BIOM
000058481 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000058481 590__ $$a12.124$$b2016
000058481 591__ $$aMULTIDISCIPLINARY SCIENCES$$b3 / 63 = 0.048$$c2016$$dQ1$$eT1
000058481 592__ $$a6.413$$b2016
000058481 593__ $$aBiochemistry, Genetics and Molecular Biology (miscellaneous)$$c2016$$dQ1
000058481 593__ $$aPhysics and Astronomy (miscellaneous)$$c2016$$dQ1
000058481 593__ $$aChemistry (miscellaneous)$$c2016$$dQ1
000058481 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000058481 700__ $$aKennedy, N.A.
000058481 700__ $$aAdams, A.T.
000058481 700__ $$aKalla, R.
000058481 700__ $$aHeath, S.
000058481 700__ $$aO''Leary, K.R.
000058481 700__ $$aDrummond, H.
000058481 700__ $$aWilson, D.C.
000058481 700__ $$aGut, I.G.
000058481 700__ $$aNimmo, E.R.
000058481 700__ $$aSatsangi, J.
000058481 700__ $$aLauc, G.
000058481 700__ $$aCampbell, H.
000058481 700__ $$aMcGovern, D.P.B.
000058481 700__ $$aAnnese, V.
000058481 700__ $$aZoldoš, V.
000058481 700__ $$aPermberton, I.K.
000058481 700__ $$aWuhrer, M.
000058481 700__ $$aKolarich, D.
000058481 700__ $$aFernandes, D.L.
000058481 700__ $$aTheorodorou, E.
000058481 700__ $$aMerrick, V.
000058481 700__ $$aSpencer, D.I.
000058481 700__ $$aGardner, R.A.
000058481 700__ $$aDoran, R.
000058481 700__ $$aShubhakar, A.
000058481 700__ $$aBoyapati, R.
000058481 700__ $$aRudan, I.
000058481 700__ $$aLionetti, P.
000058481 700__ $$aAkmacic, I.T.
000058481 700__ $$aKrištic, J.
000058481 700__ $$aVuckovic, F.
000058481 700__ $$aŠtambuk, J.
000058481 700__ $$aNovokmet, M.
000058481 700__ $$aPucic-Bakovic, M.
000058481 700__ $$aGornik, O.
000058481 700__ $$aAndriulli, A.
000058481 700__ $$aCantoro, L.
000058481 700__ $$aSturniolo, G.
000058481 700__ $$aFiorino, G.
000058481 700__ $$aManetti, N.
000058481 700__ $$aLatiano, A.
000058481 700__ $$aKohn, A.
000058481 700__ $$aD''Incà, R.
000058481 700__ $$aDanese, S.
000058481 700__ $$aArnott, I.D.
000058481 700__ $$aNoble, C.L.
000058481 700__ $$aLees, C.W.
000058481 700__ $$aShand, A.G.
000058481 700__ $$aHo, G.T
000058481 700__ $$aDunlop, M.G.
000058481 700__ $$aMurphy, L.
000058481 700__ $$aGibson, J.
000058481 700__ $$aEvenden, L.
000058481 700__ $$aWrobel, N.
000058481 700__ $$aGilchrist, T.
000058481 700__ $$aFawkes, A.
000058481 700__ $$aKammeijer, G.S.M.
000058481 700__ $$aClerc, F.
000058481 700__ $$aDe Haan, N.
000058481 700__ $$aVojta, A.
000058481 700__ $$aSamaržija, I.
000058481 700__ $$aMarkulin, D.
000058481 700__ $$aKlasic, M.
000058481 700__ $$aDobrinic, P.
000058481 700__ $$aAulchenko, Y.
000058481 700__ $$aVan, Den Heuve
000058481 700__ $$aJonkers, D.
000058481 700__ $$aPierik, M.
000058481 700__ $$aVatn, S.
000058481 700__ $$aRicanek, P.
000058481 700__ $$aJahnsen, J.
000058481 700__ $$aYou, P.
000058481 700__ $$aSølvernes, J.
000058481 700__ $$aFrengen, A.B.
000058481 700__ $$aTannæs, T.M.
000058481 700__ $$aMoen, A.E.F.
000058481 700__ $$aDahl, F.A.
000058481 700__ $$aLindstrøm, J.C.
000058481 700__ $$aEkeland, G.S.
000058481 700__ $$aDetlie, T.E.
000058481 700__ $$aKeita, A.V.
000058481 700__ $$aSöderholm, J.D.
000058481 700__ $$aHjortswang, H.
000058481 700__ $$aHalfvarson, J.
000058481 700__ $$aBergemalm, D.
000058481 700__ $$0(orcid)0000-0003-0076-3529$$aGomollón, F.$$uUniversidad de Zaragoza
000058481 700__ $$aD'Amato, M.
000058481 700__ $$aTörkvist, L.
000058481 700__ $$aHjelm, F.
000058481 700__ $$aGullberg, M.
000058481 700__ $$aNordberg, N.
000058481 700__ $$aOcklind, A.
000058481 700__ $$aPettersson, E.
000058481 700__ $$aEkman, D.
000058481 700__ $$aSundell, M.
000058481 700__ $$aModig, E.
000058481 700__ $$aVeillard, A.C.
000058481 700__ $$aSchoemans, R.
000058481 700__ $$aPoncelet, D.
000058481 700__ $$aSabatel, C.
000058481 700__ $$aGut, M.
000058481 700__ $$aBayes, M.
000058481 700__ $$aCasén, C.
000058481 700__ $$aLindahl, T.
000058481 700__ $$aCiemniejewska, E.
000058481 700__ $$aVatn, M.H.
000058481 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina
000058481 773__ $$g7 (2016), 13507 [14 pp]$$pNATURE COMMUNICATIONS$$tNature Communications$$x2041-1723
000058481 8564_ $$s665585$$uhttps://zaguan.unizar.es/record/58481/files/texto_completo.pdf$$yVersión publicada
000058481 8564_ $$s68276$$uhttps://zaguan.unizar.es/record/58481/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000058481 909CO $$ooai:zaguan.unizar.es:58481$$particulos$$pdriver
000058481 951__ $$a2020-02-21-13:40:02
000058481 980__ $$aARTICLE