58481 20200221144318.0 doi 10.1038/ncomms13507 sideral 97605 ART-2016-97605 eng Ventham, N.T. Integrative epigenome-wide analysis demonstrates that DNA methylation may mediate genetic risk in inflammatory bowel disease 2016 Access copy available to the general public Unrestricted Epigenetic alterations may provide important insights into gene-environment interaction in inflammatory bowel disease (IBD). Here we observe epigenome-wide DNA methylation differences in 240 newly-diagnosed IBD cases and 190 controls. These include 439 differentially methylated positions (DMPs) and 5 differentially methylated regions (DMRs), which we study in detail using whole genome bisulphite sequencing. We replicate the top DMP (RPS6KA2) and DMRs (VMP1, ITGB2 and TXK) in an independent cohort. Using paired genetic and epigenetic data, we delineate methylation quantitative trait loci; VMP1/microRNA-21 methylation associates with two polymorphisms in linkage disequilibrium with a known IBD susceptibility variant. Separated cell data shows that IBD-associated hypermethylation within the TXK promoter region negatively correlates with gene expression in whole-blood and CD8+ T cells, but not other cell types. Thus, site-specific DNA methylation changes in IBD relate to underlying genotype and associate with cell-specific alteration in gene expression. info:eu-repo/grantAgreement/EC/FP7/305676/EU/Inflammatory Bowel Disease CHARACTERization by a multi-modal integrated biomarker study/IBD-CHARACTER info:eu-repo/grantAgreement/EC/FP7/305479/EU/Diagnostic and prognostic biomarkers for inflammatory bowel diseaseIBD-BIOM/IBD-BIOM info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 12.124 2016 MULTIDISCIPLINARY SCIENCES 3 / 63 = 0.048 2016 Q1 T1 6.413 2016 Biochemistry, Genetics and Molecular Biology (miscellaneous) 2016 Q1 Physics and Astronomy (miscellaneous) 2016 Q1 Chemistry (miscellaneous) 2016 Q1 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Kennedy, N.A. Adams, A.T. Kalla, R. Heath, S. O''Leary, K.R. Drummond, H. Wilson, D.C. Gut, I.G. Nimmo, E.R. Satsangi, J. Lauc, G. Campbell, H. McGovern, D.P.B. Annese, V. Zoldoš, V. Permberton, I.K. Wuhrer, M. Kolarich, D. Fernandes, D.L. Theorodorou, E. Merrick, V. Spencer, D.I. Gardner, R.A. Doran, R. Shubhakar, A. Boyapati, R. Rudan, I. Lionetti, P. Akmacic, I.T. Krištic, J. Vuckovic, F. Štambuk, J. Novokmet, M. Pucic-Bakovic, M. Gornik, O. Andriulli, A. Cantoro, L. Sturniolo, G. Fiorino, G. Manetti, N. Latiano, A. Kohn, A. D''Incà, R. Danese, S. Arnott, I.D. Noble, C.L. Lees, C.W. Shand, A.G. Ho, G.T Dunlop, M.G. Murphy, L. Gibson, J. Evenden, L. Wrobel, N. Gilchrist, T. Fawkes, A. Kammeijer, G.S.M. Clerc, F. De Haan, N. Vojta, A. Samaržija, I. Markulin, D. Klasic, M. Dobrinic, P. Aulchenko, Y. Van, Den Heuve Jonkers, D. Pierik, M. Vatn, S. Ricanek, P. Jahnsen, J. You, P. Sølvernes, J. Frengen, A.B. Tannæs, T.M. Moen, A.E.F. Dahl, F.A. Lindstrøm, J.C. Ekeland, G.S. Detlie, T.E. Keita, A.V. Söderholm, J.D. Hjortswang, H. Halfvarson, J. Bergemalm, D. (orcid)0000-0003-0076-3529 Gomollón, F. Universidad de Zaragoza D'Amato, M. Törkvist, L. Hjelm, F. Gullberg, M. Nordberg, N. Ocklind, A. Pettersson, E. Ekman, D. Sundell, M. Modig, E. Veillard, A.C. Schoemans, R. Poncelet, D. Sabatel, C. Gut, M. Bayes, M. Casén, C. Lindahl, T. Ciemniejewska, E. Vatn, M.H. 1007 610 Universidad de Zaragoza Dpto. Medicina, Psiqu. y Derm. Area Medicina 7 (2016), 13507 [14 pp] NATURE COMMUNICATIONS Nature Communications 2041-1723 665585 http://zaguan.unizar.es/record/58481/files/texto_completo.pdf Versión publicada 68276 http://zaguan.unizar.es/record/58481/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:58481 articulos driver 2020-02-21-13:40:02 ARTICLE