000058515 001__ 58515 000058515 005__ 20170504085637.0 000058515 0247_ $$2doi$$a10.1186/1297-9716-43-43 000058515 0248_ $$2sideral$$a80069 000058515 037__ $$aART-2012-80069 000058515 041__ $$aeng 000058515 100__ $$aCrespo, H. 000058515 245__ $$aMannose receptor may be involved in small ruminant lentivirus pathogenesis 000058515 260__ $$c2012 000058515 5060_ $$aAccess copy available to the general public$$fUnrestricted 000058515 5203_ $$aThirty-one sheep naturally infected with small ruminant lentiviruses (SRLV) of known genotype (A or B), and clinically affected with neurological disease, pneumonia or arthritis were used to analyse mannose receptor (MR) expression (transcript levels) and proviral load in virus target tissues (lung, mammary gland, CNS and carpal joints). Control sheep were SRLV-seropositive asymptomatic (n¿=¿3), seronegative (n¿=¿3) or with chronic listeriosis, pseudotuberculosis or parasitic cysts (n¿=¿1 in each case). MR expression and proviral load increased with the severity of lesions in most analyzed organs of the SRLV infected sheep and was detected in the affected tissue involved in the corresponding clinical disease (CNS, lung and carpal joint in neurological disease, pneumonia and arthritis animal groups, respectively). The increased MR expression appeared to be SRLV specific and may have a role in lentiviral pathogenesis. 000058515 536__ $$9info:eu-repo/grantAgreement/ES/CICYT/AGL2010-22341-C04-01 000058515 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/ 000058515 590__ $$a3.426$$b2012 000058515 591__ $$aVETERINARY SCIENCES$$b1 / 142 = 0.007$$c2012$$dQ1$$eT1 000058515 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion 000058515 700__ $$aJauregui, P. 000058515 700__ $$aGlaria, I. 000058515 700__ $$aSanjosé, L. 000058515 700__ $$aPolledo, L. 000058515 700__ $$aGarcía-Marín, J.F. 000058515 700__ $$0(orcid)0000-0002-2053-9842$$aLuján, L.$$uUniversidad de Zaragoza 000058515 700__ $$aDe Andrés, D. 000058515 700__ $$aAmorena, B. 000058515 700__ $$aReina, R. 000058515 7102_ $$11009$$2773$$aUniversidad de Zaragoza$$bDepartamento de Patología Animal$$cSanidad Animal 000058515 773__ $$g43, 43 (2012), []$$pVet. res.$$tVETERINARY RESEARCH$$x0928-4249 000058515 8564_ $$s433707$$uhttps://zaguan.unizar.es/record/58515/files/texto_completo.pdf$$yVersión publicada 000058515 8564_ $$s114030$$uhttps://zaguan.unizar.es/record/58515/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada 000058515 909CO $$ooai:zaguan.unizar.es:58515$$particulos$$pdriver 000058515 951__ $$a2017-05-04-08:51:31 000058515 980__ $$aARTICLE