58515 20170504085637.0 doi 10.1186/1297-9716-43-43 sideral 80069 ART-2012-80069 eng Crespo, H. Mannose receptor may be involved in small ruminant lentivirus pathogenesis 2012 Access copy available to the general public Unrestricted Thirty-one sheep naturally infected with small ruminant lentiviruses (SRLV) of known genotype (A or B), and clinically affected with neurological disease, pneumonia or arthritis were used to analyse mannose receptor (MR) expression (transcript levels) and proviral load in virus target tissues (lung, mammary gland, CNS and carpal joints). Control sheep were SRLV-seropositive asymptomatic (n¿=¿3), seronegative (n¿=¿3) or with chronic listeriosis, pseudotuberculosis or parasitic cysts (n¿=¿1 in each case). MR expression and proviral load increased with the severity of lesions in most analyzed organs of the SRLV infected sheep and was detected in the affected tissue involved in the corresponding clinical disease (CNS, lung and carpal joint in neurological disease, pneumonia and arthritis animal groups, respectively). The increased MR expression appeared to be SRLV specific and may have a role in lentiviral pathogenesis. info:eu-repo/grantAgreement/ES/CICYT/AGL2010-22341-C04-01 info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 3.426 2012 VETERINARY SCIENCES 1 / 142 = 0.007 2012 Q1 T1 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Jauregui, P. Glaria, I. Sanjosé, L. Polledo, L. García-Marín, J.F. (orcid)0000-0002-2053-9842 Luján, L. Universidad de Zaragoza De Andrés, D. Amorena, B. Reina, R. 1009 773 Universidad de Zaragoza Departamento de Patología Animal Sanidad Animal 43, 43 (2012), [] Vet. res. VETERINARY RESEARCH 0928-4249 433707 http://zaguan.unizar.es/record/58515/files/texto_completo.pdf Versión publicada 114030 http://zaguan.unizar.es/record/58515/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:58515 articulos driver 2017-05-04-08:51:31 ARTICLE