000060411 001__ 60411
000060411 005__ 20190709135423.0
000060411 0247_ $$2doi$$a10.1109/TBME.2016.2554614
000060411 0248_ $$2sideral$$a94142
000060411 037__ $$aART-2017-94142
000060411 041__ $$aeng
000060411 100__ $$aBarquero-Pérez, Ó
000060411 245__ $$aOn the Influence of Heart Rate and Coupling Interval Prematurity on Heart Rate Turbulence
000060411 260__ $$c2017
000060411 5060_ $$aAccess copy available to the general public$$fUnrestricted
000060411 5203_ $$aObjective: Heart rate turbulence (HRT) has been successfully explored for cardiac risk stratification. While HRT is known to be influenced by the heart rate (HR) and the coupling interval (CI), nonconcordant results have been reported on how the CI influences HRT. The purpose of this study is to investigate HRT changes in terms of CI and HR by means of an especially designed protocol. Methods: A dataset was acquired from 11 patients with structurally normal hearts for which CI was altered by different pacing trains and HR by isoproterenol during electrophysiological study (EPS). The protocol was designed so that, first, the effect of HR changes on HRT and, second, the combined effect of HR and CI could be explored. As a complement to the EPS dataset, a database of 24-h Holters from 61 acute myocardial infarction (AMI) patients was studied for the purpose of assessing risk. Data analysis was performed by using different nonlinear ridge regression models, and the relevance of model variables was assessed using resampling methods. The EPS subjects, with and without isoproterenol, were analyzed separately. Results: The proposed nonlinear regression models were found to account for the influence of HR and CI on HRT, both in patients undergoing EPS without isoproterenol and in low-risk AMI patients, whereas this influence was absent in high-risk AMI patients. Moreover, model coefficients related to CI were not statistically significant, p > 0.05, on EPS subjects with isoproterenol. Conclusion: The observed relationship between CI and HRT, being in agreement with the baroreflex hypothesis, was statistically significant (p < 0.05), when decoupling the effect of HR and normalizing the CI by the HR. Significance: The results of this study can help to provide new risk indicators that take into account physiological influence on HRT, as well as to model how this influence changes in different cardiac conditions.
000060411 536__ $$9info:eu-repo/grantAgreement/ES/MINECO/TEC2013-42140-R$$9info:eu-repo/grantAgreement/ES/MINECO/TEC2013-48439-C4-1-R$$9info:eu-repo/grantAgreement/ES/MINECO/TEC2013-48439-C4-2-R$$9info:eu-repo/grantAgreement/ES/MINECO/TIN2014-5356-R
000060411 540__ $$9info:eu-repo/semantics/openAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000060411 590__ $$a4.288$$b2017
000060411 591__ $$aENGINEERING, BIOMEDICAL$$b9 / 78 = 0.115$$c2017$$dQ1$$eT1
000060411 592__ $$a1.267$$b2017
000060411 593__ $$aBiomedical Engineering$$c2017$$dQ1
000060411 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000060411 700__ $$aFiguera, C.
000060411 700__ $$aGoya-Esteban, R.
000060411 700__ $$aMora-Jiménez, I.
000060411 700__ $$aGimeno-Blanes, F. J.
000060411 700__ $$0(orcid)0000-0003-3434-9254$$aLaguna, P.$$uUniversidad de Zaragoza
000060411 700__ $$0(orcid)0000-0002-7503-3339$$aMartínez, J.P.$$uUniversidad de Zaragoza
000060411 700__ $$0(orcid)0000-0001-7285-0715$$aGil, E.$$uUniversidad de Zaragoza
000060411 700__ $$aSörnmo, L.
000060411 700__ $$aGarcía-Alberola, A.
000060411 700__ $$aRojo-Álvarez J.L.
000060411 7102_ $$15007$$2520$$aUniversidad de Zaragoza$$bDpto. Informát.Ingenie.Sistms.$$cÁrea Ingen.Sistemas y Automát.
000060411 7102_ $$15008$$2800$$aUniversidad de Zaragoza$$bDpto. Ingeniería Electrón.Com.$$cÁrea Teoría Señal y Comunicac.
000060411 773__ $$g64, 2 (2017), 302-309$$pIEEE trans. biomed. eng.$$tIEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING$$x0018-9294
000060411 8564_ $$s2161463$$uhttps://zaguan.unizar.es/record/60411/files/texto_completo.pdf$$yPostprint
000060411 8564_ $$s159435$$uhttps://zaguan.unizar.es/record/60411/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint
000060411 909CO $$ooai:zaguan.unizar.es:60411$$particulos$$pdriver
000060411 951__ $$a2019-07-09-11:27:46
000060411 980__ $$aARTICLE