60606 20200221144246.0 doi 10.1016/j.diagmicrobio.2016.02.021 sideral 94412 ART-2016-94412 eng (orcid)0000-0003-0920-8628 González-Domínguez, Maria Genotypic and phenotypic characterization of methicillin-resistant Staphylococcus aureus (MRSA) clones with high-level mupirocin resistance 2016 Access copy available to the general public Unrestricted An elevated proportion (27.2%) of high-level mupirocin-resistant methicillin-resistant Staphylococcus aureus (HLMUPR-MRSA) isolates were found in our environment in one year period. HLMUPR-MRSA isolates were mainly collected from skin and soft tissue samples, and diabetes was the main related comorbidity condition. These isolates were more frequently found in vascular surgery. HLMUPR-MRSA were more resistant to aminoglycosides than mupirocin-susceptible MRSA, linked to the presence of bifunctional and/or nucleotidyltransferase enzymes with/without macrolide resistance associated with the msr(A) gene. Most of HLMUPR-MRSA isolates belonged to ST125/t067. Nine IS257-ileS2 amplification patterns (p3 was the most frequent) were observed in HLMUPR-MRSA isolates, suggesting the presence of several mupirocin-resistance-carrying plasmids in our environment and promoting the emergence of mupirocin resistance. The presence of the same IS257-ileS2 amplification pattern p3 in 65% of HLMUPR-MRSA, all of them ST125/t067, suggests a clonal spread in our hospital and community environment which could explain the high prevalence of HLMUPR-MRSA during the study period. An outbreak situation or an increase in mupirocin consumption was not observed. info:eu-repo/grantAgreement/ES/DGA/B24-211130 info:eu-repo/semantics/openAccess by-nc-nd http://creativecommons.org/licenses/by-nc-nd/3.0/es/ 2.401 2016 MICROBIOLOGY 64 / 124 = 0.516 2016 Q3 T2 INFECTIOUS DISEASES 47 / 84 = 0.56 2016 Q3 T2 1.237 2016 Medicine (miscellaneous) 2016 Q1 Microbiology (medical) 2016 Q2 Infectious Diseases 2016 Q2 info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion (orcid)0000-0002-9742-1463 Seral, Cristina Universidad de Zaragoza Potel, Carmen Sáenz, Yolanda Alvarez, Maximiliano Torres, Carmen (orcid)0000-0002-2519-701X Castillo, Francisco Javier Universidad de Zaragoza 1008 630 Universidad de Zaragoza Dpto. Microb.Med.Pr.,Sal.Públ. Área Microbiología 85 (2016), 213-217 Diagn. microbiol. infect. dis. Diagnostic Microbiology and Infectious Disease 0732-8893 355040 http://zaguan.unizar.es/record/60606/files/texto_completo.pdf Postprint 108370 http://zaguan.unizar.es/record/60606/files/texto_completo.jpg?subformat=icon icon Postprint oai:zaguan.unizar.es:60606 articulos driver 2020-02-21-13:25:24 ARTICLE