doi:10.3390/molecules200915807engAuria-Luna, FernandoMarqués-López, EugeniaMohammadi, SomayehHeiran, RoghayehHerrera, P.R.New Organocatalytic Asymmetric Synthesis of Highly Substituted Chiral 2-Oxospiro-[indole-3,4'- (1',4'-dihydropyridine)] DerivativesART-2015-98041Herein, we report our preliminary results concerning the first promising asymmetric synthesis of highly functionalized 2-oxospiro-indole-3, 4'-(1', 4'-dihydropyridine)] via the reaction of an enamine with isatylidene malononitrile derivatives in the presence of a chiral base organocatalyst. The moderate, but promising, enantioselectivity observed (30%–58% ee (enantiomeric excess)) opens the door to a new area of research for the asymmetric construction of these appealing spirooxindole skeletons, whose enantioselective syntheses are still very limited.2015http://zaguan.unizar.es/record/6066110.3390/molecules200915807http://zaguan.unizar.es/record/60661oai:zaguan.unizar.es:60661info:eu-repo/grantAgreement/ES/DGA/E104info:eu-repo/grantAgreement/ES/MICINN/CTQ2013-44367-C2-1-Pinfo:eu-repo/grantAgreement/ES/UZ/JIUZ-2014-CIE-07Molecules 20, 9 (2015), 15807-15826byhttp://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccess