60661 20210121114503.0 doi 10.3390/molecules200915807 sideral 98041 ART-2015-98041 eng (orcid)0000-0002-3726-0493 Auria-Luna, Fernando New Organocatalytic Asymmetric Synthesis of Highly Substituted Chiral 2-Oxospiro-[indole-3,4'- (1',4'-dihydropyridine)] Derivatives 2015 Access copy available to the general public Unrestricted Herein, we report our preliminary results concerning the first promising asymmetric synthesis of highly functionalized 2-oxospiro-indole-3, 4'-(1', 4'-dihydropyridine)] via the reaction of an enamine with isatylidene malononitrile derivatives in the presence of a chiral base organocatalyst. The moderate, but promising, enantioselectivity observed (30%–58% ee (enantiomeric excess)) opens the door to a new area of research for the asymmetric construction of these appealing spirooxindole skeletons, whose enantioselective syntheses are still very limited. info:eu-repo/grantAgreement/ES/DGA/E104 info:eu-repo/grantAgreement/ES/MICINN/CTQ2013-44367-C2-1-P info:eu-repo/grantAgreement/ES/UZ/JIUZ-2014-CIE-07 info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 2.465 2015 CHEMISTRY, ORGANIC 24 / 59 = 0.407 2015 Q2 T2 0.57 2015 Analytical Chemistry 2015 Q2 Chemistry (miscellaneous) 2015 Q2 Drug Discovery 2015 Q2 Physical and Theoretical Chemistry 2015 Q2 Medicine (miscellaneous) 2015 Q2 Organic Chemistry 2015 Q2 Pharmaceutical Science 2015 Q2 Molecular Medicine 2015 Q3 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion (orcid)0000-0001-6832-8983 Marqués-López, Eugenia Universidad de Zaragoza Mohammadi, Somayeh Heiran, Roghayeh (orcid)0000-0002-5244-9569 Herrera, P.R. Universidad de Zaragoza 2013 765 Universidad de Zaragoza Dpto. Química Orgánica Área Química Orgánica 20, 9 (2015), 15807-15826 Molecules Molecules 1420-3049 1291012 http://zaguan.unizar.es/record/60661/files/texto_completo.pdf Versión publicada 76696 http://zaguan.unizar.es/record/60661/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:60661 articulos driver 2021-01-21-10:52:19 ARTICLE