000060679 001__ 60679 000060679 005__ 20230210140617.0 000060679 0247_ $$2doi$$a10.1371/journal.pone.0172741 000060679 0248_ $$2sideral$$a98222 000060679 037__ $$aART-2017-98222 000060679 041__ $$aeng 000060679 100__ $$aRomero-Sanchiz, Pablo 000060679 245__ $$aEconomic evaluation of a guided and unguided internet-based CBT intervention for major depression: Results from a multicenter, three-armed randomized controlled trial conducted in primary care 000060679 260__ $$c2017 000060679 5060_ $$aAccess copy available to the general public$$fUnrestricted 000060679 5203_ $$aDepression is one of the most common mental disorders and will become one of the leading causes of disability in the world. Internet-based CBT programs for depression have been classified as "well established" following the American Psychological Association criteria for empirically supported treatments. The aim of this study is to analyze the cost effectiveness at 12-month follow-up of the Internet-based CBT program "Smiling is fun" with (LITG) and without psychotherapist support (TSG) compared to usual care. The perspective used in our analysis is societal. A sample of 296 depressed patients (mean age of 43.04 years; 76% female; BDI-II mean score = 22.37) from primary care services in four Spanish regions were randomized in the RCT. The complete case and intention-to-treat (ITT) perspectives were used for the analyses. The results demonstrated that both Internet-based CBT interventions exhibited cost utility and cost effectiveness compared with a control group. The complete case analyses revealed an incremental cost-effectiveness ratio (ICER) of €-169.50 and an incremental cost-utility ratio (ICUR) of €-11389.66 for the TSG group and an ICER of €-104.63 and an ICUR of €-6380.86 for the LITG group. The ITT analyses found an ICER of €-98.37 and an ICUR of €-5160.40 for the TSG group and an ICER of €-9.91 and an ICUR of €496.72 for the LITG group. In summary, the results of this study indicate that the two Internet-based CBT interventions are appropriate from both economic and clinical perspectives for depressed patients in the Spanish primary care system. These interventions not only help patients to improve clinically but also generate societal savings. 000060679 536__ $$9info:eu-repo/grantAgreement/ES/ISCIII/CB06-03$$9info:eu-repo/grantAgreement/ES/ISCIII/CM13-00115$$9info:eu-repo/grantAgreement/ES/ISCIII/CP14-00087$$9info:eu-repo/grantAgreement/ES/ISCIII/RD12-0005$$9info:eu-repo/grantAgreement/ES/MINECO/PI10-01083 000060679 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/ 000060679 590__ $$a2.766$$b2017 000060679 591__ $$aMULTIDISCIPLINARY SCIENCES$$b15 / 64 = 0.234$$c2017$$dQ1$$eT1 000060679 592__ $$a1.164$$b2017 000060679 593__ $$aAgricultural and Biological Sciences (miscellaneous)$$c2017$$dQ1 000060679 593__ $$aMedicine (miscellaneous)$$c2017$$dQ1 000060679 593__ $$aBiochemistry, Genetics and Molecular Biology (miscellaneous)$$c2017$$dQ1 000060679 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion 000060679 700__ $$aNogueira-Arjona, Raquel 000060679 700__ $$aGarcía-Ruiz, Antonio 000060679 700__ $$aLuciano, Juan V. 000060679 700__ $$0(orcid)0000-0002-3797-4218$$aGarcía Campayo, Javier$$uUniversidad de Zaragoza 000060679 700__ $$aGili, Margalida 000060679 700__ $$aBotella, Cristina 000060679 700__ $$aBaños, Rosa 000060679 700__ $$aCastro, Adoración 000060679 700__ $$0(orcid)0000-0002-1690-4130$$aLópez-Del-Hoyo, Yolanda$$uUniversidad de Zaragoza 000060679 700__ $$aPérez Ara, María Ángeles 000060679 700__ $$0(orcid)0000-0003-1575-7738$$aModrego-Alarcón, Marta 000060679 700__ $$aMayoral Cleríes, Fermín 000060679 7102_ $$14009$$2730$$aUniversidad de Zaragoza$$bDpto. Psicología y Sociología$$cÁrea Psicología Básica 000060679 7102_ $$11007$$2745$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Psiquiatría 000060679 773__ $$g12, 2 (2017), e0172741 [15 pp.]$$pPLoS One$$tPLoS ONE$$x1932-6203 000060679 8564_ $$s1865408$$uhttps://zaguan.unizar.es/record/60679/files/texto_completo.pdf$$yVersión publicada 000060679 8564_ $$s115586$$uhttps://zaguan.unizar.es/record/60679/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada 000060679 909CO $$ooai:zaguan.unizar.es:60679$$particulos$$pdriver 000060679 951__ $$a2023-02-10-13:59:35 000060679 980__ $$aARTICLE