000060709 001__ 60709
000060709 005__ 20190709135446.0
000060709 0247_ $$2doi$$a10.2147/IJN.S116749
000060709 0248_ $$2sideral$$a98160
000060709 037__ $$aART-2017-98160
000060709 041__ $$aeng
000060709 100__ $$aKeller, L.
000060709 245__ $$aNanoengineered implant as a new platform for regenerative nanomedicine using 3D well-organized human cell spheroids
000060709 260__ $$c2017
000060709 5060_ $$aAccess copy available to the general public$$fUnrestricted
000060709 5203_ $$aIn tissue engineering, it is still rare today to see clinically transferable strategies for tissue-engineered graft production that conclusively offer better tissue regeneration than the already existing technologies, decreased recovery times, and less risk of complications. Here a novel tissue-engineering concept is presented for the production of living bone implants combining 1) a nanofibrous and microporous implant as cell colonization matrix and 2) 3D bone cell spheroids. This combination, double 3D implants, shows clinical relevant thicknesses for the treatment of an early stage of bone lesions before the need of bone substitutes. The strategy presented here shows a complete closure of a defect in nude mice calvaria after only 31 days. As a novel strategy for bone regenerative nanomedicine, it holds great promises to enhance the therapeutic efficacy of living bone implants.
000060709 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc$$uhttp://creativecommons.org/licenses/by-nc/3.0/es/
000060709 590__ $$a4.37$$b2017
000060709 591__ $$aPHARMACOLOGY & PHARMACY$$b31 / 261 = 0.119$$c2017$$dQ1$$eT1
000060709 591__ $$aNANOSCIENCE & NANOTECHNOLOGY$$b35 / 92 = 0.38$$c2017$$dQ2$$eT2
000060709 592__ $$a1.225$$b2017
000060709 593__ $$aBioengineering$$c2017$$dQ1
000060709 593__ $$aBiomaterials$$c2017$$dQ1
000060709 593__ $$aBiophysics$$c2017$$dQ1
000060709 593__ $$aOrganic Chemistry$$c2017$$dQ1
000060709 593__ $$aMedicine (miscellaneous)$$c2017$$dQ1
000060709 593__ $$aDrug Discovery$$c2017$$dQ1
000060709 593__ $$aNanoscience and Nanotechnology$$c2017$$dQ2
000060709 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000060709 700__ $$aIdoux-Gillet, Y.
000060709 700__ $$aWagner, Q.
000060709 700__ $$aEap, S.
000060709 700__ $$aBrasse, D.
000060709 700__ $$aSchwinté, P.
000060709 700__ $$0(orcid)0000-0003-3165-0156$$aArruebo, M.$$uUniversidad de Zaragoza
000060709 700__ $$aBenkirane-Jessel, N.
000060709 7102_ $$15005$$2555$$aUniversidad de Zaragoza$$bDpto. Ing.Quím.Tecnol.Med.Amb.$$cÁrea Ingeniería Química
000060709 773__ $$g12 (2017), 447-457$$pInt. j. nanomed.$$tInternational Journal of Nanomedicine$$x1176-9114
000060709 8564_ $$s5094232$$uhttps://zaguan.unizar.es/record/60709/files/texto_completo.pdf$$yVersión publicada
000060709 8564_ $$s110300$$uhttps://zaguan.unizar.es/record/60709/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000060709 909CO $$ooai:zaguan.unizar.es:60709$$particulos$$pdriver
000060709 951__ $$a2019-07-09-11:38:34
000060709 980__ $$aARTICLE