000060727 001__ 60727 000060727 005__ 20200221144342.0 000060727 0247_ $$2doi$$a10.1371/journal.pone.0151856 000060727 0248_ $$2sideral$$a95655 000060727 037__ $$aART-2016-95655 000060727 041__ $$aeng 000060727 100__ $$aDe Torres, J.P. 000060727 245__ $$aIs COPD a progressive disease? A long term BODE cohort observation 000060727 260__ $$c2016 000060727 5060_ $$aAccess copy available to the general public$$fUnrestricted 000060727 5203_ $$aBackgroundThe Global Initiative for Obstructive Lung Diseases (GOLD) defines COPD as a disease that is usually progressive. GOLD also provides a spirometric classification of airflow limitation. However, little is known about the long-term changes of patients in different GOLD grades.ObjectiveExplore the proportion and characteristics of COPD patients that change their spirometric GOLD grade over long-term follow-up.MethodsPatients alive for at least 8 years since recruitment and those who died with at least 4 years of repeated spirometric measurements were selected from the BODE cohort database. We purposely included the group of non survivors to avoid a “survival selection” bias. The proportion of patients that had a change (improvement or worsening) in their spirometric GOLD grading was calculated and their characteristics compared with those that remained in the same grade.ResultsA total of 318 patients were included in the survivor and 217 in the non-survivor groups. Nine percent of survivors and 11% of non survivors had an improvement of at least one GOLD grade. Seventy one percent of survivors and non-survivors remained in the same GOLD grade. Those that improved had a greater degree of airway obstruction at baseline.ConclusionsIn this selected population of COPD patients, a high proportion of patients remained in the same spirometric GOLD grade or improved in a long-term follow-up. These findings suggest that once diagnosed, COPD is usually a non-progressive disease. 000060727 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/ 000060727 590__ $$a2.806$$b2016 000060727 591__ $$aMULTIDISCIPLINARY SCIENCES$$b15 / 63 = 0.238$$c2016$$dQ1$$eT1 000060727 592__ $$a1.236$$b2016 000060727 593__ $$aAgricultural and Biological Sciences (miscellaneous)$$c2016$$dQ1 000060727 593__ $$aMedicine (miscellaneous)$$c2016$$dQ1 000060727 593__ $$aBiochemistry, Genetics and Molecular Biology (miscellaneous)$$c2016$$dQ1 000060727 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion 000060727 700__ $$0(orcid)0000-0001-9096-2294$$aMarín, J.M.$$uUniversidad de Zaragoza 000060727 700__ $$aPinto-Plata, V. 000060727 700__ $$aDivo, M. 000060727 700__ $$aSanchez-Salcedo, P. 000060727 700__ $$aZagaceta, J. 000060727 700__ $$aZulueta, J.J. 000060727 700__ $$aBerto, J. 000060727 700__ $$aCabrera, C. 000060727 700__ $$aCelli, B.R. 000060727 700__ $$aCasanova, C. 000060727 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina 000060727 773__ $$g11, 4 (2016), 0151856 [10 p]$$pPLoS One$$tPloS one$$x1932-6203 000060727 8564_ $$s936797$$uhttps://zaguan.unizar.es/record/60727/files/texto_completo.pdf$$yVersión publicada 000060727 8564_ $$s85266$$uhttps://zaguan.unizar.es/record/60727/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada 000060727 909CO $$ooai:zaguan.unizar.es:60727$$particulos$$pdriver 000060727 951__ $$a2020-02-21-13:50:40 000060727 980__ $$aARTICLE